Spermine-Based Poly(β-amino ester)s for siRNA Delivery against Mutated KRAS in Lung Cancer.
KRAS
PBAE
lung cancer
poly(β-amino ester)s
siRNA delivery
spermine
Journal
Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791
Informations de publication
Date de publication:
04 09 2023
04 09 2023
Historique:
pmc-release:
04
09
2024
medline:
5
9
2023
pubmed:
14
8
2023
entrez:
14
8
2023
Statut:
ppublish
Résumé
Polyethylenimine (PEI) is a highly efficient cationic polymer for nucleic acid delivery, and although it is commonly used in preclinical studies, its clinical application is limited because of concerns regarding its cytotoxicity. Poly(β-amino ester)s are a new group of biodegradable and biocompatible cationic polymers that can be used for siRNA delivery. In this study, we synthesized Boc-protected and deprotected poly(β-amino ester)s, P(BSpBAE) and P(SpBAE), respectively, based on spermine and 1,4-butanediol diacrylate to deliver siRNA. The polymers were synthesized by Michael addition in a step-growth polymerization and characterized via
Identifiants
pubmed: 37578116
doi: 10.1021/acs.molpharmaceut.3c00206
pmc: PMC7615020
mid: EMS185245
doi:
Substances chimiques
poly(beta-amino ester)
0
RNA, Small Interfering
0
Spermine
2FZ7Y3VOQX
Proto-Oncogene Proteins p21(ras)
EC 3.6.5.2
Polymers
0
Polyethyleneimine
9002-98-6
KRAS protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4505-4516Subventions
Organisme : European Research Council
ID : 637830
Pays : International
Références
J Am Chem Soc. 2003 May 7;125(18):5316-23
pubmed: 12720443
Science. 1982 Sep 3;217(4563):937-9
pubmed: 6287573
Nanoscale. 2019 Nov 28;11(44):21433-21448
pubmed: 31681915
Acta Biomater. 2016 Sep 1;41:293-301
pubmed: 27262740
Mol Ther. 2005 Mar;11(3):426-34
pubmed: 15727939
Adv Healthc Mater. 2019 Jan;8(2):e1801359
pubmed: 30549448
J Cell Biol. 1982 Nov;95(2 Pt 1):676-81
pubmed: 6183281
Chem Commun (Camb). 2013 Jun 11;49(46):5319-21
pubmed: 23646347
Acc Chem Res. 2008 Jun;41(6):749-59
pubmed: 18507402
Nanoscale Res Lett. 2020 Aug 17;15(1):165
pubmed: 32804261
Front Bioeng Biotechnol. 2020 Jul 30;8:916
pubmed: 32850752
Cancer Gene Ther. 2016 Apr;23(4):73-82
pubmed: 26987292
Adv Drug Deliv Rev. 2012 Jan;64(1):1-15
pubmed: 21356260
Biomaterials. 2012 May;33(13):3594-603
pubmed: 22341939
Anal Biochem. 1999 Mar 15;268(2):278-88
pubmed: 10075818
Pharm Res. 2019 Jul 9;36(9):133
pubmed: 31289919
J Control Release. 2013 Apr 10;167(1):101-7
pubmed: 22995755
Nanomaterials (Basel). 2019 Jul 08;9(7):
pubmed: 31288448
J Thorac Oncol. 2019 May;14(5):876-889
pubmed: 30735816
Nature. 2010 Mar 18;464(7287):436-40
pubmed: 20173739
ACS Macro Lett. 2014 Aug 19;3(8):829-833
pubmed: 35590709
Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):1996-2001
pubmed: 26112463
Cancer Res. 2006 Apr 15;66(8):3992-5
pubmed: 16618717
Bioconjug Chem. 2019 Feb 20;30(2):263-272
pubmed: 30452233
Adv Drug Deliv Rev. 2009 Aug 10;61(10):850-62
pubmed: 19422869
ACS Nano. 2013 May 28;7(5):3767-77
pubmed: 23597090
J Mater Chem B. 2018 Nov 21;6(43):6904-6918
pubmed: 32254575
Cell. 2000 Mar 31;101(1):25-33
pubmed: 10778853
Nat Rev Genet. 2002 Oct;3(10):737-47
pubmed: 12360232
ACS Appl Mater Interfaces. 2018 Jun 6;10(22):18585-18600
pubmed: 29749228
J Control Release. 2010 Aug 3;145(3):182-95
pubmed: 20226220
Nano Lett. 2009 Jun;9(6):2402-6
pubmed: 19422265
Biomacromolecules. 2014 Apr 14;15(4):1299-310
pubmed: 24552396
Nature. 2003 Jun 5;423(6940):573-4
pubmed: 12789298
Expert Rev Med Devices. 2011 Mar;8(2):173-85
pubmed: 21381910
Biomacromolecules. 2014 Oct 13;15(10):3634-42
pubmed: 25308336
Expert Opin Drug Deliv. 2020 Mar;17(3):275-277
pubmed: 31951752