Inherited chitinases enable sustained growth and rapid dispersal of bacteria from chitin particles.


Journal

Nature microbiology
ISSN: 2058-5276
Titre abrégé: Nat Microbiol
Pays: England
ID NLM: 101674869

Informations de publication

Date de publication:
09 2023
Historique:
received: 08 08 2022
accepted: 04 07 2023
medline: 31 8 2023
pubmed: 15 8 2023
entrez: 14 8 2023
Statut: ppublish

Résumé

Many biogeochemical functions involve bacteria utilizing solid substrates. However, little is known about the coordination of bacterial growth with the kinetics of attachment to and detachment from such substrates. In this quantitative study of Vibrio sp. 1A01 growing on chitin particles, we reveal the heterogeneous nature of the exponentially growing culture comprising two co-existing subpopulations: a minority replicating on chitin particles and a non-replicating majority which was planktonic. This partition resulted from a high rate of cell detachment from particles. Despite high detachment, sustained exponential growth of cells on particles was enabled by the enrichment of extracellular chitinases excreted and left behind by detached cells. The 'inheritance' of these chitinases sustains the colonizing subpopulation despite its reduced density. This simple mechanism helps to circumvent a trade-off between growth and dispersal, allowing particle-associated marine heterotrophs to explore new habitats without compromising their fitness on the habitat they have already colonized.

Identifiants

pubmed: 37580592
doi: 10.1038/s41564-023-01444-5
pii: 10.1038/s41564-023-01444-5
doi:

Substances chimiques

Chitin 1398-61-4
Chitinases EC 3.2.1.14

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1695-1705

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Ghita Guessous (G)

Department of Physics, University of California at San Diego, La Jolla, CA, USA.

Vadim Patsalo (V)

Department of Integrative Structural and Computational Biology, and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA.
DataBricks, San Diego, CA, USA.

Rohan Balakrishnan (R)

Department of Physics, University of California at San Diego, La Jolla, CA, USA.

Tolga Çağlar (T)

Department of Physics, University of California at San Diego, La Jolla, CA, USA.
San Diego Supercomputer Center, La Jolla, CA, USA.

James R Williamson (JR)

Department of Integrative Structural and Computational Biology, and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA.

Terence Hwa (T)

Department of Physics, University of California at San Diego, La Jolla, CA, USA. hwa@ucsd.edu.

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