Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects.

Humans NAD / metabolism Sequestosome-1 Protein / metabolism Antioxidants / metabolism NF-E2-Related Factor 2 / genetics Oxidation-Reduction Inflammation / drug therapy
CD4(+) T cell NAD(+) boosting Th17 cell arginine biosynthesis nicotinamide riboside nrf2 psoriasis

Journal

Cell reports. Medicine
ISSN: 2666-3791
Titre abrégé: Cell Rep Med
Pays: United States
ID NLM: 101766894

Informations de publication

Date de publication:
19 09 2023
Historique:
received: 01 12 2022
revised: 23 05 2023
accepted: 18 07 2023
medline: 22 9 2023
pubmed: 17 8 2023
entrez: 16 8 2023
Statut: ppublish

Résumé

To evaluate whether nicotinamide adenine dinucleotide-positive (NAD

Identifiants

DOI: 10.1016/j.xcrm.2023.101157 PMID: 37586364 PMC: PMC10518596
pubmed: 37586364
pii: S2666-3791(23)00310-5
doi: 10.1016/j.xcrm.2023.101157
pmc: PMC10518596
pii:
doi:

Substances chimiques

NAD 0U46U6E8UK
Sequestosome-1 Protein 0
Antioxidants 0
NF-E2-Related Factor 2 0

Banques de données

ClinicalTrials.gov
['NCT01934660', 'NCT02812238', 'NCT01143454', 'NCT00001846']

Types de publication

Journal Article Research Support, N.I.H., Intramural Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

101157

Subventions

Organisme : Medical Research Council
ID : MR/P011705/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P011705/2
Pays : United Kingdom
Organisme : NIH HHS
ID : S10 OD021562
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA HL005102
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Published by Elsevier Inc.

Déclaration de conflit d'intérêts

Declaration of interests The NR and matching placebo were supplied by Chromadex Inc. (Los Angeles, CA, USA) under a Cooperative and Development Research Agreement (CRADA).

Références

Br J Pharmacol. 2022 May;179(9):1839-1856
pubmed: 33817782
FEBS J. 2015 Dec;282(24):4672-8
pubmed: 26432171
Cell Metab. 2016 Dec 13;24(6):795-806
pubmed: 28068222
J Clin Invest. 2015 Nov 03;125(12):4592-600
pubmed: 26529255
Cell Rep. 2021 Aug 10;36(6):109516
pubmed: 34380043
Cutis. 2009 Sep;84(3):163-8
pubmed: 19842576
Trends Biochem Sci. 2007 Jan;32(1):12-9
pubmed: 17161604
Wiley Interdiscip Rev RNA. 2019 Mar;10(2):e1512
pubmed: 30353673
Annu Rev Immunol. 2021 Apr 26;39:395-416
pubmed: 33902315
Cell Rep. 2019 Aug 13;28(7):1717-1728.e6
pubmed: 31412242
Cell Metab. 2022 Apr 5;34(4):516-532.e11
pubmed: 35316657
Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1876-E1885
pubmed: 29432159
Cell Metab. 2015 Sep 1;22(3):485-98
pubmed: 26299452
Antioxidants (Basel). 2021 Dec 07;10(12):
pubmed: 34943060
Cell Metab. 2019 May 7;29(5):1104-1118.e6
pubmed: 30773462
Food Chem Toxicol. 2018 May;115:315-328
pubmed: 29577948
N Engl J Med. 2015 Oct 22;373(17):1618-26
pubmed: 26488693
Sci Rep. 2016 May 27;6:26933
pubmed: 27230286
J Immunol. 2012 Aug 15;189(4):1639-47
pubmed: 22798682
Sci Rep. 2016 Dec 12;6:38619
pubmed: 27941837
J Neurosci. 2006 Sep 20;26(38):9794-804
pubmed: 16988050
Cell Rep. 2021 Jan 5;34(1):108588
pubmed: 33406435
OMICS. 2012 May;16(5):284-7
pubmed: 22455463
Curr Opin Rheumatol. 2015 Mar;27(2):127-33
pubmed: 25599143
J Clin Invest. 2020 Nov 2;130(11):6054-6063
pubmed: 32790648
Cell Metab. 2021 Jun 1;33(6):1076-1087
pubmed: 33930322
Nat Immunol. 2019 Oct;20(10):1311-1321
pubmed: 31527833
Cell Metab. 2022 Mar 1;34(3):396-407.e6
pubmed: 35235774
Physiol Rep. 2019 Jul;7(12):e14139
pubmed: 31207144
Trends Immunol. 2020 Nov;41(11):1037-1050
pubmed: 33055013
Neuro Endocrinol Lett. 2012;33(6):643-50
pubmed: 23160220
Cell Rep. 2020 Jan 7;30(1):112-123.e4
pubmed: 31914379
JACC Basic Transl Sci. 2022 Sep 14;7(12):1183-1196
pubmed: 36644285
Circulation. 2017 Jul 18;136(3):263-276
pubmed: 28483812
Nat Metab. 2021 Mar;3(3):318-326
pubmed: 33723462
Sci Transl Med. 2021 Feb 10;13(580):
pubmed: 33568522
Cell Rep. 2020 Feb 11;30(6):1898-1909.e4
pubmed: 32049019
Genome Res. 2003 Nov;13(11):2498-504
pubmed: 14597658
J Biol Chem. 2020 Dec 25;295(52):17986-17996
pubmed: 33051211
Nat Immunol. 2020 Dec;21(12):1540-1551
pubmed: 33020660
Nutrients. 2015 Feb 18;7(3):1426-63
pubmed: 25699985
N Engl J Med. 2012 Mar 29;366(13):1190-9
pubmed: 22455413
Cell Rep. 2019 Nov 19;29(8):2144-2153.e7
pubmed: 31747589
J Biol Chem. 2010 Jul 16;285(29):22576-91
pubmed: 20452972
Int J Physiol Pathophysiol Pharmacol. 2014 Jul 12;6(2):102-8
pubmed: 25057336
N Engl J Med. 2003 Nov 20;349(21):2014-22
pubmed: 14627786
Rheumatol Int. 2013 Oct;33(10):2597-605
pubmed: 23722874
J Clin Invest. 2018 Aug 31;128(9):3651-3661
pubmed: 30059015
J Clin Invest. 2022 Mar 1;132(5):
pubmed: 35025762
Metabolism. 2014 Apr;63(4):492-501
pubmed: 24467914
Front Immunol. 2018 Aug 02;9:1682
pubmed: 30127781
Cell Metab. 2011 Oct 5;14(4):528-36
pubmed: 21982712
Signal Transduct Target Ther. 2021 Jan 1;6(1):2
pubmed: 33384409
Blood. 2007 Jan 15;109(2):632-42
pubmed: 16985181
JAMA Cardiol. 2017 Sep 1;2(9):1013-1018
pubmed: 28564678
PLoS One. 2012;7(7):e42357
pubmed: 22848760
Nucleic Acids Res. 2009 Jan;37(Database issue):D412-6
pubmed: 18940858

Auteurs

Kim Han (K)

Laboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA.

Komudi Singh (K)

Laboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA.

Allison M Meadows (AM)

Laboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA; Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK.

Rahul Sharma (R)

Laboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA.

Shahin Hassanzadeh (S)

Laboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA.

Jing Wu (J)

Laboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA.

Haley Goss-Holmes (H)

Laboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA.

Rebecca D Huffstutler (RD)

Cardiovascular Branch, NHLBI, NIH, Bethesda, MD, USA.

Heather L Teague (HL)

Laboratory of Cardiometabolic Disease and Inflammation, NHLBI, NIH, Bethesda, MD, USA.

Nehal N Mehta (NN)

Laboratory of Cardiometabolic Disease and Inflammation, NHLBI, NIH, Bethesda, MD, USA.

Julian L Griffin (JL)

Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK; The Rowett Institute, School of Medicine, Medical Sciences and Nutrition, Foresterhill Campus, Aberdeen, UK.

Rong Tian (R)

Mitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, WA, USA.

Javier Traba (J)

Laboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA; Instituto Universitario de Biología Molecular-UAM (IUBM-UAM), Departamento de Biología Molecular, Universidad Autónoma de Madrid, Madrid, Spain; Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain.

Michael N Sack (MN)

Laboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA; Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK. Electronic address: sackm@nih.gov.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Boosting NAD preferentially blunts Th17...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides adényliques › NAD › Boosting NAD preferentially blunts Th17...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Séquestosome-1 › Boosting NAD preferentially blunts Th17...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents protecteurs › Antioxydants › Boosting NAD preferentially blunts Th17...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteur-2 apparenté à NF-E2 › Boosting NAD preferentially blunts Th17...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Boosting NAD preferentially blunts Th17...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Boosting NAD preferentially blunts Th17...