Management of Acquired Factor X Deficiency Caused by In Vitro Non-neutralizing Anti-factor X Autoantibodies with Pre-emptive Corticosteroid Therapy.
acquired hemophilia
corticosteroid
factor X deficiency
Journal
Internal medicine (Tokyo, Japan)
ISSN: 1349-7235
Titre abrégé: Intern Med
Pays: Japan
ID NLM: 9204241
Informations de publication
Date de publication:
2023
2023
Historique:
medline:
18
8
2023
pubmed:
17
8
2023
entrez:
16
8
2023
Statut:
ppublish
Résumé
Coagulation factor X (FX) deficiency causes severe hemorrhagic symptoms. We herein report a 90-year-old man with hemorrhagic symptoms and prolongation of prothrombin time (PT) and activated partial thromboplastin time (APTT). Cross-mixing tests showed a factor deficiency pattern, but administration of plasma products was not effective. Acquired coagulation factor deficiency was suspected, and immunosuppressive therapy was started. After the intervention, his hemorrhagic symptoms improved. A decrease in FX activity was later confirmed, and anti-FX autoantibody was retrospectively detected by an enzyme-linked immunosorbent assay. Immediate intervention is important for patients suspected of having acquired coagulation factor deficiency.
Identifiants
pubmed: 37587057
doi: 10.2169/internalmedicine.0849-22
pmc: PMC10484778
doi:
Substances chimiques
Adrenal Cortex Hormones
0
Autoantibodies
0
Blood Coagulation Factors
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2401-2406Références
Clin Case Rep. 2015 Jul;3(7):587-93
pubmed: 26273448
Blood Cells Mol Dis. 2014 Feb-Mar;52(2-3):116-20
pubmed: 24074948
Intern Med. 2020 May 15;59(10):1303-1308
pubmed: 32023586
Blood. 2001 Mar 15;97(6):1885-7
pubmed: 11238135
Semin Thromb Hemost. 2022 Mar;48(2):206-218
pubmed: 34942668
Thromb Haemost. 2022 Mar;122(3):320-328
pubmed: 33930902
Haemophilia. 2019 Mar;25(2):e106-e109
pubmed: 30570186
Ann Hematol. 2013 Oct;92(10):1437-8
pubmed: 23463452
Hematology Am Soc Hematol Educ Program. 2019 Dec 6;2019(1):80-87
pubmed: 31808848
Acta Haematol. 2013;129(1):40-4
pubmed: 23107910
Haemophilia. 2012 Sep;18(5):655-63
pubmed: 23437437
Blood Rev. 2017 Jan;31(1):37-45
pubmed: 27542511