Enhancement of cellular uptake by increasing the number of encapsulated gold nanoparticles in polymeric micelles.

Micelles Gold / chemistry Metal Nanoparticles / chemistry Polymers / chemistry Polyethylene Glycols / chemistry
Block copolymers Cancer therapy Cell uptake Gold nanoparticles Micelles Nanomedicine

Journal

Journal of colloid and interface science
ISSN: 1095-7103
Titre abrégé: J Colloid Interface Sci
Pays: United States
ID NLM: 0043125

Informations de publication

Date de publication:
15 Dec 2023
Historique:
received: 24 03 2023
revised: 07 08 2023
accepted: 09 08 2023
medline: 4 10 2023
pubmed: 18 8 2023
entrez: 17 8 2023
Statut: ppublish

Résumé

We apply a combination of polycaprolactone (PCL)-thiol ligand functionalization with flow-controlled microfluidic block copolymer self-assembly to produce biocompatible gold nanoparticle (GNP)-loaded micellar polymer nanoparticles (GNP-PNPs) in which GNPs are encapsulated within PCL cores surrounded by an external layer of poly(ethylene glycol) (PEG). By varying both the relative amount of block copolymer and the microfluidic flow rate, a series of GNP-PNPs are produced in which the mean number of GNPs per PNP in the < 50-nm fraction (Z

Identifiants

DOI: 10.1016/j.jcis.2023.08.060 PMID: 37591076
pubmed: 37591076
pii: S0021-9797(23)01541-2
doi: 10.1016/j.jcis.2023.08.060
pii:
doi:

Substances chimiques

Micelles 0
Gold 7440-57-5
Polymers 0
Polyethylene Glycols 3WJQ0SDW1A

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

142-154

Informations de copyright

Copyright © 2023 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Sundiata Kly (S)

Department of Chemistry, University of Victoria, PO Box 1700 Stn CSC, Victoria, BC V8W 2Y2, Canada.

Yuhang Huang (Y)

Department of Chemistry, University of Victoria, PO Box 1700 Stn CSC, Victoria, BC V8W 2Y2, Canada.

Matthew G Moffitt (MG)

Department of Chemistry, University of Victoria, PO Box 1700 Stn CSC, Victoria, BC V8W 2Y2, Canada. Electronic address: mmoffitt@uvic.ca.

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Classifications MeSH

questionsmedicales.fr › Préparations pharmaceutiques › Micelles › Enhancement of cellular uptake by increasing...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Or › Enhancement of cellular uptake by increasing...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Nanoparticules métalliques › Enhancement of cellular uptake by increasing...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Enhancement of cellular uptake by increasing...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyéthylène glycols › Enhancement of cellular uptake by increasing...