Fragrance allergens in cosmetic products marketed for children in Denmark.


Journal

Contact dermatitis
ISSN: 1600-0536
Titre abrégé: Contact Dermatitis
Pays: England
ID NLM: 7604950

Informations de publication

Date de publication:
Nov 2023
Historique:
revised: 19 06 2023
received: 03 05 2023
accepted: 03 08 2023
medline: 5 10 2023
pubmed: 18 8 2023
entrez: 17 8 2023
Statut: ppublish

Résumé

Fragrances are among the most common contact allergens in children. Cosmetic products are the most frequent source of skin exposure. To investigate exposure to fragrance allergens among Danish children, based on a sample of 1179 cosmetic products marketed for children. Information regarding cosmetic products marketed to children was obtained using a non-profit smartphone application registry, with data from December 2015 to November 2022. The number of validated products was 26  537, of which 1349 marketed for children. After elimination of duplicates, 1179 (4.4%) individual products remained. The majority 53.8% (634/1179) of the products were fragranced. The highest frequency of declared fragrances was found in 'Facial care'-products: 93.0% (80/86), of which 97.7% were lip balms. The highest number of labelled fragrances in one single product (n = 16) was found in a baby perfume. Fragrance mix I (FMI) or II (FMII) allergens were found in 25.3% (298/1179) of the products. Limonene and linalool were the two most frequently labelled fragrance allergens. Children can be exposed to a vast number of fragrance allergens from scented cosmetic products. Allergens from FM I and FMII are widely used in cosmetic products marketed to children. Patch testing with FMI and FMII remains relevant in children.

Sections du résumé

BACKGROUND BACKGROUND
Fragrances are among the most common contact allergens in children. Cosmetic products are the most frequent source of skin exposure.
OBJECTIVE OBJECTIVE
To investigate exposure to fragrance allergens among Danish children, based on a sample of 1179 cosmetic products marketed for children.
METHODS METHODS
Information regarding cosmetic products marketed to children was obtained using a non-profit smartphone application registry, with data from December 2015 to November 2022.
RESULTS RESULTS
The number of validated products was 26  537, of which 1349 marketed for children. After elimination of duplicates, 1179 (4.4%) individual products remained. The majority 53.8% (634/1179) of the products were fragranced. The highest frequency of declared fragrances was found in 'Facial care'-products: 93.0% (80/86), of which 97.7% were lip balms. The highest number of labelled fragrances in one single product (n = 16) was found in a baby perfume. Fragrance mix I (FMI) or II (FMII) allergens were found in 25.3% (298/1179) of the products. Limonene and linalool were the two most frequently labelled fragrance allergens.
CONCLUSION CONCLUSIONS
Children can be exposed to a vast number of fragrance allergens from scented cosmetic products. Allergens from FM I and FMII are widely used in cosmetic products marketed to children. Patch testing with FMI and FMII remains relevant in children.

Identifiants

pubmed: 37591237
doi: 10.1111/cod.14397
doi:

Substances chimiques

Allergens 0
Perfume 0
Cyclohexenes 0
Cosmetics 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

374-381

Informations de copyright

© 2023 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.

Références

Schnuch A, Griem P. Fragrances as allergens. Allergo J Int. 2018;27(6):173-183. doi:10.1007/S40629-018-0075-X
IFRA. Transparency List. Accessed October 13, 2022 https://ifrafragrance.org/priorities/ingredients/ifra-transparency-list
Uter W, Johansen JD, Börje A, et al. Categorization of fragrance contact allergens for prioritization of preventive measures: clinical and experimental data and consideration of structure-activity relationships. Contact Dermatitis. 2013;69(4):196-230. doi:10.1111/COD.12117
Regulation (EC) No 1223/2009 of the European Parliament and of the Council of 30 November 2009 on cosmetic products (recast) (Text with EEA relevance). Accessed June 13, 2023 https://www.legislation.gov.uk/eur/2009/1223/contents
Uter W, Gefeller O, Giménez-Arnau A, et al. Characteristics of patients patch tested in the European surveillance system on contact allergies (ESSCA) network, 2009-2012. Contact Dermatitis. 2015;73(2):82-90. doi:10.1111/COD.12409
Uter W, Amario-Hita JC, Balato A, et al. European surveillance system on contact allergies (ESSCA): results with the European baseline series, 2013/14. J Eur Acad Dermatol Venereol. 2017;31(9):1516-1525. doi:10.1111/JDV.14423
Bruze M, Mowitz M, Ofenloch R, et al. The significance of batch and patch test method in establishing contact allergy to fragrance mix I-EDEN fragrance study group. Contact Dermatitis. 2019;81(2):104-109. doi:10.1111/COD.13253
Diepgen TL, Ofenloch R, Bruze M, et al. Prevalence of fragrance contact allergy in the general population of five European countries: a cross-sectional study. Br J Dermatol. 2015;173(6):1411-1419. doi:10.1111/BJD.14151
Alinaghi F, Bennike NH, Egeberg A, Thyssen JP, Johansen JD. Prevalence of contact allergy in the general population: a systematic review and meta-analysis. Contact Dermatitis. 2019;80(2):77-85. doi:10.1111/cod.13119
Buckley DA, Rycroft RJG, White IR, Mcfadden JP. The frequency of fragrance allergy in patch-tested patients increases with their age. Br J Dermatol. 2003;149(5):986-989. doi:10.1111/J.1365-2133.2003.05491.X
Heisterberg MV, Menné T, Johansen JD. Fragrance allergy and quality of life-a case-control study. Contact Dermatitis. 2014;70(2):81-89. doi:10.1111/cod.12128
Vigan M, Castelain F. Fragrance and cosmetic contact allergy in children. Curr Treat Options Allergy. 2014;1(3):310-316. doi:10.1007/S40521-014-0027-8
Lagrelius M, Wahlgren CF, Matura M, Kull I, Lidén C. High prevalence of contact allergy in adolescence: results from the population-based BAMSE birth cohort. Contact Dermatitis. 2016;74(1):44-51. doi:10.1111/COD.12492
Simonsen AB, Foss-Skiftesvik MH, Thyssen JP, et al. Contact allergy in Danish children: current trends. Contact Dermatitis. 2018;79(5):295-302. doi:10.1111/COD.13079
Belloni Fortina A, Cooper SM, Spiewak R, Fontana E, Schnuch A, Uter W. Patch test results in children and adolescents across Europe. Analysis of the ESSCA network 2002-2010. Pediatr Allergy Immunol. 2015;26(5):446-455. doi:10.1111/PAI.12397
Kemiluppen: Tjek din personlige pleje for uønsket kemi. Accessed May 5, 2022. https://taenk.dk/kemi/plejeprodukter-og-kosmetik/kemiluppen-tjek-din-personlige-pleje-uoensket-kemi
About us | Forbrugerrådet Taenk. Accessed January 6, 2023. https://taenk.dk/about-us
Smith VM, Clark SM, Wilkinson M. Allergic contact dermatitis in children: trends in allergens, 10 years on. A retrospective study of 500 children tested between 2005 and 2014 in one UK centre. Contact Dermatitis. 2016;74(1):37-43. doi:10.1111/COD.12489
Bonamonte D, Hansel K, Romita P, et al. Contact allergy in children with and without atopic dermatitis: An Italian multicentre study. Contact Dermatitis. 2022;87(3):265-272. Accessed January 2, 2023. https://pubmed.ncbi.nlm.nih.gov/35451136/
Noë E, Huygens S, Morren MA, Garmyn M, Goossens A, Gilissen L. Contact allergy in a paediatric population observed in a tertiary referral Centre in Belgium. Contact Dermatitis. 2022;86(1):3-8. doi:10.1111/COD.13975
Peiser M, Tralau T, Heidler J, et al. Allergic contact dermatitis: epidemiology, molecular mechanisms, in vitro methods and regulatory aspects. Cell Mol Life Sci. 2011;69(5):763-781. doi:10.1007/S00018-011-0846-8
Rastogi SC, Heydorn S, Johansen JD, Basketter DA. Fragrance chemicals in domestic and occupational products. Contact Dermatitis. 2001;45(4):221-225. Accessed May 4, 2022. doi:10.1034/j.1600-0536.2001.450406.x
Friedmann PS. The relationships between exposure dose and response in induction and elicitation of contact hypersensitivity in humans. Br J Dermatol. 2007;157(6):1093-1102. doi:10.1111/J.1365-2133.2007.08162.X
Pap EB, Temesvári E, Németh I, Sárdy M, Pónyai G. Contact hypersensitivity in adolescents. Pediatr Dermatol. 2018;35(6):769-773. doi:10.1111/PDE.13609
Uter W, Yazar K, Kratz EM, Mildau G, Lidén C. Coupled exposure to ingredients of cosmetic products: I. Fragrances. Contact Dermatitis. 2013;69(6):335-341. doi:10.1111/COD.12125
Bonefeld CM, Geisler C, Gimenéz-Arnau E, Lepoittevin JP, Uter W, Johansen JD. Immunological, chemical and clinical aspects of exposure to mixtures of contact allergens. Contact Dermatitis. 2017;77(3):133-142. doi:10.1111/COD.12847
van Oosten EJ, Schuttelaar MLA, Coenraads PJ. Clinical relevance of positive patch test reactions to the 26 EU-labelled fragrances. Contact Dermatitis. 2009;61(4):217-223.
Oosterhaven JAF, Uter W, Aberer W, et al. European surveillance system on contact allergies (ESSCA): contact allergies in relation to body sites in patients with allergic contact dermatitis. Contact Dermatitis. 2019;80(5):263-272. doi:10.1111/cod.13192
Sköld M, Börje A, Harambasic E, Karlberg AT. Contact allergens formed on air exposure of linalool. identification and quantification of primary and secondary oxidation products and the effect on skin sensitization. Chem Res Toxicol. 2004;17(12):1697-1705. doi:10.1021/TX049831Z
Andersch Björkman Y, Hagvall L, Siwmark C, Niklasson B, Karlberg AT, Christensson JB. Air-oxidized linalool elicits eczema in allergic patients-a repeated open application test study. Contact Dermatitis. 2014;70(3):129-138. doi:10.1111/COD.12163
Bråred Christensson J, Karlberg AT, Andersen KE, et al. Oxidized limonene and oxidized linalool-concomitant contact allergy to common fragrance terpenes. Contact Dermatitis. 2016;74(5):273-280. doi:10.1111/COD.12545
Bennike NH, Palangi L, Christensson JB, et al. Allergic contact dermatitis caused by hydroperoxides of limonene and dose-response relationship-a repeated open application test (ROAT) study. Contact Dermatitis. 2019;80(4):208-216. doi:10.1111/COD.13168
Dittmar D, Schuttelaar MLA. Contact sensitization to hydroperoxides of limonene and linalool; results of consecutive patch testing and clinical relevance: patch testing hydroperoxides of limonene/linalool. Contact Dermatitis. 2018;80:101-109. doi:10.1111/cod.13137
Bennike NH, Zachariae C, Johansen JD. Non-mix fragrances are top sensitizers in consecutive dermatitis patients - a cross-sectional study of the 26 EU-labelled fragrance allergens. Contact Dermatitis. 2017;77(5):270-279. doi:10.1111/COD.12822
EUR-Lex-32017R1410-EN-EUR-Lex. Accessed July 7, 2022. https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=celex%3A32017R1410
EUR-Lex-32021R1902-EN-EUR-Lex. Accessed March 15, 2023. https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=celex%3A32021R1902
Opinion concerning Oakmoss/Treemoss Extracts And Appropriate Consumer Information adopted by the SCCNFP during the 14th plenary meeting of 24 October 2000 | Scientific Committees. Accessed June 13, 2023 https://ec.europa.eu/health/scientific_committees/consumer_safety/opinions/sccnfp_opinions_97_04/sccp_out124_en.htm
Joulain D, Tabacchi R. Lichen extracts as raw materials in perfumery. Part 1: oakmoss. Flavour Fragr J. 2009;24(2):49-61. doi:10.1002/FFJ.1916
Joulain D, Tabacchi R. Lichen extracts as raw materials in perfumery. Part 2: treemoss. Flavour Fragr J. 2009;24(3):105-116. doi:10.1002/FFJ.1923
EUR-Lex-32009R1223-EN-EUR-Lex. Accessed June 12, 2023. https://eur-lex.europa.eu/legal-content/DA/TXT/?uri=celex%3A32009R1223
Basketter DA, Alépée N, Ashikaga T, et al. Categorization of chemicals according to their relative human skin sensitizing potency. Dermatitis. 2014;25(1):11-21. doi:10.1097/DER.0000000000000003
Emmons WW, Marks JG. Immediate and delayed reactions to cosmetic ingredients. Contact Dermatitis. 1985;13(4):258-265. doi:10.1111/J.1600-0536.1985.TB02560.X
Frosch PJ, Pilz B, Andersen KE, et al. Patch testing with fragrances: results of a multicenter study of the European environmental and contact dermatitis research group with 48 frequently used constituents of perfumes. Contact Dermatitis. 1995;33(5):333-342. doi:10.1111/j.1600-0536.1995.tb02048.x
Tanaka S, Matsumoto Y, Dlova N, et al. Immediate contact reactions to fragrance mix constituents and Myroxylon pereirae resin. Contact Dermatitis. 2004;51(1):20-21. doi:10.1111/J.0105-1873.2004.00326.X
Comstock JR, Reeder MJ. Accuracy of product ingredient labeling: comparing drugstore products with online databases and online retailers. Dermatitis. 2020;31:106-111. doi:10.1097/DER.0000000000000553
Rastogi SC, Johansen JD, Menné T. Natural ingredients based cosmetics. Content of selected fragrance sensitizers. Contact Dermatitis. 1996;34(6):423-426. doi:10.1111/J.1600-0536.1996.TB02246.X
Rastogi SC, Johansen JD, Bossi R. Selected important fragrance sensitizers in perfumes-current exposures. Contact Dermatitis. 2007;56(4):201-204. doi:10.1111/J.1600-0536.2007.01067.X
Buckley DA. Fragrance ingredient labelling in products on sale in the U.K. Br J Dermatol. 2007;157(2):295-300. doi:10.1111/J.1365-2133.2007.08018.X
Yazar K, Johnsson S, Lind ML, Boman A, Lidén C. Preservatives and fragrances in selected consumer-available cosmetics and detergents. Contact Dermatitis. 2011;64(5):265-272. doi:10.1111/J.1600-0536.2010.01828.X
Bennike NH, Oturai NB, Müller S, et al. Fragrance contact allergens in 5588 cosmetic products identified through a novel smartphone application. J Eur Acad Dermatol Venereol. 2018;32(1):79-85. doi:10.1111/JDV.14513
Celeiro M, Lamas JP, Garcia-Jares C, Llompart M. Pressurized liquid extraction-gas chromatography-mass spectrometry analysis of fragrance allergens, musks, phthalates and preservatives in baby wipes. J Chromatogr A. 2015;1384:9-21. doi:10.1016/J.CHROMA.2015.01.049

Auteurs

Sofia Botvid (S)

The National Allergy Research Centre (Videncenter for Allergi), Department of Allergy, Dermatology and Venerology, Copenhagen University Hospital Herlev-Gentofte, Gentofte Hospital, Hellerup, Denmark.
Faculty of Health and Medical Sciences, Department of Clinical Medicine, University of Copenhagen, Copenhagen N, Denmark.

Anne Birgitte Simonsen (AB)

The National Allergy Research Centre (Videncenter for Allergi), Department of Allergy, Dermatology and Venerology, Copenhagen University Hospital Herlev-Gentofte, Gentofte Hospital, Hellerup, Denmark.
Faculty of Health and Medical Sciences, Department of Clinical Medicine, University of Copenhagen, Copenhagen N, Denmark.

Claus Jørgensen (C)

The Danish Consumer Council THINK Chemicals (Forbrugerrådet TAENK Kemi), Copenhagen N, Denmark.

Stine Müller (S)

The Danish Consumer Council THINK Chemicals (Forbrugerrådet TAENK Kemi), Copenhagen N, Denmark.

Christel Søgaard Kirkeby (CS)

The Danish Consumer Council THINK Chemicals (Forbrugerrådet TAENK Kemi), Copenhagen N, Denmark.

Anne Beck Christensen (AB)

The Danish Consumer Council THINK Chemicals (Forbrugerrådet TAENK Kemi), Copenhagen N, Denmark.

Jeanne Duus Johansen (JD)

The National Allergy Research Centre (Videncenter for Allergi), Department of Allergy, Dermatology and Venerology, Copenhagen University Hospital Herlev-Gentofte, Gentofte Hospital, Hellerup, Denmark.
Faculty of Health and Medical Sciences, Department of Clinical Medicine, University of Copenhagen, Copenhagen N, Denmark.

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