Interactions of organophosphate flame retardants with human drug transporters.
Drug transporter
Flame retardants
Hepatic cells
Human exposure
Pollutant
Toxicokinetics
Journal
Ecotoxicology and environmental safety
ISSN: 1090-2414
Titre abrégé: Ecotoxicol Environ Saf
Pays: Netherlands
ID NLM: 7805381
Informations de publication
Date de publication:
15 Sep 2023
15 Sep 2023
Historique:
received:
10
06
2023
revised:
04
08
2023
accepted:
07
08
2023
medline:
20
9
2023
pubmed:
20
8
2023
entrez:
19
8
2023
Statut:
ppublish
Résumé
Organophosphate flame retardants (OPFRs) are environmental pollutants of increasing interest, widely distributed in the environment and exerting possible deleterious effects towards the human health. The present study investigates in vitro their possible interactions with human drug transporters, which are targets for environmental chemicals and actors of their toxicokinetics. Some OPFRs, i.e., tris(2-butoxyethyl) phosphate (TBOEP), tris(1,3-dichloroisopropyl) phosphate (TDCPP), tri-o-cresyl phosphate (TOCP) and triphenyl phosphate (TPHP), were found to inhibit activities of some transporters, such as organic anion transporter 3 (OAT3), organic anion transporting polypeptide (OATP) 1B1, OATP1B3, organic cation transporter 2 (OCT2) or breast cancer resistance protein (BCRP). These effects were concentration-dependent, with IC
Identifiants
pubmed: 37597291
pii: S0147-6513(23)00852-7
doi: 10.1016/j.ecoenv.2023.115348
pii:
doi:
Substances chimiques
tri-o-cresyl phosphate
X8II18JD0A
ATP Binding Cassette Transporter, Subfamily G, Member 2
0
Flame Retardants
0
Neoplasm Proteins
0
triphenyl phosphate
YZE19Z66EA
Tritolyl Phosphates
0
Membrane Transport Proteins
0
Environmental Pollutants
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
115348Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.