Qi-Po-Sheng-Mai granule ameliorates Ach-CaCl
Atrial fibrillation
Calcium homeostasis
Network pharmacology
Single nucleus sequencing
Traditional Chinese medicine
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
ISSN: 1618-095X
Titre abrégé: Phytomedicine
Pays: Germany
ID NLM: 9438794
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
06
04
2023
revised:
15
07
2023
accepted:
06
08
2023
medline:
31
8
2023
pubmed:
20
8
2023
entrez:
19
8
2023
Statut:
ppublish
Résumé
Atrial fibrillation (AF) is one of the most common arrhythmias encountered in clinical settings. Currently, the pathophysiology of AF remains unclear, which severely limits the effectiveness and safety of medical therapies. The Chinese herbal formula Qi-Po-Sheng-Mai Granule (QPSM) has been widely used in China to treat AF. However, its pharmacological and molecular mechanisms remain unknown. The purpose of this study was to investigate the molecular mechanisms and potential targets of QPSM for AF. The AF model was induced by Ach (66 μg/ml) and CaCl Based on an Ach-CaCl The present study has systematically elucidated the role of QPSM in maintaining calcium homeostasis in cardiomyocytes through the regulation of calcium transporters, which could lead to new drug development ideas for AF.
Sections du résumé
BACKGROUND
BACKGROUND
Atrial fibrillation (AF) is one of the most common arrhythmias encountered in clinical settings. Currently, the pathophysiology of AF remains unclear, which severely limits the effectiveness and safety of medical therapies. The Chinese herbal formula Qi-Po-Sheng-Mai Granule (QPSM) has been widely used in China to treat AF. However, its pharmacological and molecular mechanisms remain unknown.
PURPOSE
OBJECTIVE
The purpose of this study was to investigate the molecular mechanisms and potential targets of QPSM for AF.
STUDY DESIGN AND METHODS
METHODS
The AF model was induced by Ach (66 μg/ml) and CaCl
RESULTS
RESULTS
Based on an Ach-CaCl
CONCLUSION
CONCLUSIONS
The present study has systematically elucidated the role of QPSM in maintaining calcium homeostasis in cardiomyocytes through the regulation of calcium transporters, which could lead to new drug development ideas for AF.
Identifiants
pubmed: 37597360
pii: S0944-7113(23)00378-1
doi: 10.1016/j.phymed.2023.155017
pii:
doi:
Substances chimiques
Calcium
SY7Q814VUP
Calcium Chloride
M4I0D6VV5M
Bone Density Conservation Agents
0
Amino Acids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
155017Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier GmbH.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.