Molecularly imprinted polymer hydrogel sheets with metalloporphyrin-incorporated molecular recognition sites for protein capture.

Metalloporphyrins are often found in nature as coordination recognition sites within biological process, and synthetically offer the potential for use in therapeutic, catalytic and diagnostic applications. While porphyrin containing biological recognition elements have stability limitations, molecularly imprinted polymers bearing these structures offer an alternative with excellent robustness and the ability to work in extreme conditions. In this work, we synthesised a polymerizable porphyrin and metalloporphyrin and have incorporated these as co-monomers within a hydrogel thin-sheet MIP for the specific recognition of bovine haemoglobin (BHb). The hydrogels were evaluated using Scatchard analysis, with K

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Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.