A review on surfactin: molecular regulation of biosynthesis.
Biosynthesis process
Global regulation
Surfactin
Synthesis pathway regulation
srfA operon
Journal
Archives of microbiology
ISSN: 1432-072X
Titre abrégé: Arch Microbiol
Pays: Germany
ID NLM: 0410427
Informations de publication
Date de publication:
21 Aug 2023
21 Aug 2023
Historique:
received:
13
06
2023
accepted:
07
08
2023
revised:
06
08
2023
medline:
22
8
2023
pubmed:
21
8
2023
entrez:
21
8
2023
Statut:
epublish
Résumé
Surfactin has many biological activities, such as inhibiting plant diseases, resisting bacteria, fungi, viruses, tumors, mycoplasma, anti-adhesion, etc. It has great application potential in agricultural biological control, clinical medical treatment, environmental treatment and other fields. However, the low yield has been the bottleneck of its popularization and application. It is very important to understand the synthesis route and control strategy of surfactin to improve its yield and purity. In this paper, based on the biosynthetic pathway and regulatory factors of surfactin, its biosynthesis regulation strategy was comprehensively summarized, involving enhancement of endogenous and exogenous precursor supply, modification of the synthesis pathway of lipid chain and peptide chain, improvement of secretion and efflux, and manipulation some global regulatory factors, such as Spo0A, AbrB, ComQXP, phrCSF, etc. to directly or indirectly stimulate surfactin synthesis. And the current production and separation and purification process of surfactin are briefly described. This review also provides a scientific reference for promoting surfactin production and its applications in various fields.
Identifiants
pubmed: 37603063
doi: 10.1007/s00203-023-03652-3
pii: 10.1007/s00203-023-03652-3
doi:
Types de publication
Review
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
313Subventions
Organisme : National Natural Science Foundation of China
ID : 32172468
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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