Fungal COP9 signalosome assembly requires connection of two trimeric intermediates for integration of intrinsic deneddylase.


Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
29 08 2023
Historique:
medline: 23 8 2023
pubmed: 21 8 2023
entrez: 21 8 2023
Statut: ppublish

Résumé

The conserved eight-subunit COP9 signalosome (CSN) is required for multicellular fungal development. The CSN deneddylase cooperates with the Cand1 exchange factor to control replacements of E3 ubiquitin cullin RING ligase receptors, providing specificity to eukaryotic protein degradation.

Identifiants

pubmed: 37603767
doi: 10.1073/pnas.2305049120
pmc: PMC10477865
doi:

Substances chimiques

COP9 Signalosome Complex EC 3.4.19.12
Ubiquitin-Protein Ligases EC 2.3.2.27

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2305049120

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Auteurs

Fruzsina Bakti (F)

Department of Molecular Microbiology and Genetics, Institute of Microbiology and Genetics, Goettingen Center for Molecular Biosciences, University of Goettingen, 37077 Goettingen, Germany.

Helena Stupperich (H)

Department of Molecular Microbiology and Genetics, Institute of Microbiology and Genetics, Goettingen Center for Molecular Biosciences, University of Goettingen, 37077 Goettingen, Germany.

Kerstin Schmitt (K)

Department of Molecular Microbiology and Genetics, Institute of Microbiology and Genetics, Goettingen Center for Molecular Biosciences, University of Goettingen, 37077 Goettingen, Germany.

Oliver Valerius (O)

Department of Molecular Microbiology and Genetics, Institute of Microbiology and Genetics, Goettingen Center for Molecular Biosciences, University of Goettingen, 37077 Goettingen, Germany.

Anna M Köhler (AM)

Department of Molecular Microbiology and Genetics, Institute of Microbiology and Genetics, Goettingen Center for Molecular Biosciences, University of Goettingen, 37077 Goettingen, Germany.

Cindy Meister (C)

Department of Molecular Microbiology and Genetics, Institute of Microbiology and Genetics, Goettingen Center for Molecular Biosciences, University of Goettingen, 37077 Goettingen, Germany.

Anja Strohdiek (A)

Department of Molecular Microbiology and Genetics, Institute of Microbiology and Genetics, Goettingen Center for Molecular Biosciences, University of Goettingen, 37077 Goettingen, Germany.

Rebekka Harting (R)

Department of Molecular Microbiology and Genetics, Institute of Microbiology and Genetics, Goettingen Center for Molecular Biosciences, University of Goettingen, 37077 Goettingen, Germany.

Christoph Sasse (C)

Department of Molecular Microbiology and Genetics, Institute of Microbiology and Genetics, Goettingen Center for Molecular Biosciences, University of Goettingen, 37077 Goettingen, Germany.

Kai Heimel (K)

Department of Microbial Cell Biology, Institute of Microbiology and Genetics, Goettingen Center for Molecular Biosciences, University of Goettingen, 37077 Goettingen, Germany.

Piotr Neumann (P)

Department of Molecular Structural Biology, Institute of Microbiology and Genetics, Goettingen Center for Molecular Biosciences, University of Goettingen, 37077 Goettingen, Germany.

Ralf Ficner (R)

Department of Molecular Structural Biology, Institute of Microbiology and Genetics, Goettingen Center for Molecular Biosciences, University of Goettingen, 37077 Goettingen, Germany.

Gerhard H Braus (GH)

Department of Molecular Microbiology and Genetics, Institute of Microbiology and Genetics, Goettingen Center for Molecular Biosciences, University of Goettingen, 37077 Goettingen, Germany.

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Classifications MeSH