Discovery of Highly Selective and Orally Bioavailable PI3Kδ Inhibitors with Anti-Inflammatory Activity for Treatment of Acute Lung Injury.

Animals Mice Molecular Docking Simulation Acute Lung Injury / drug therapy Amines Anti-Inflammatory Agents / pharmacology Biological Availability

Journal

Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531

Informations de publication

Date de publication:
14 09 2023
Historique:
medline: 15 9 2023
pubmed: 22 8 2023
entrez: 22 8 2023
Statut: ppublish

Résumé

PI3Kδ is a promising target for the treatment of inflammatory disease; however, the application of PI3Kδ inhibitors in acute respiratory inflammatory diseases is rarely investigated. In this study, through scaffold hopping design, we report a new series of 1

Identifiants

DOI: 10.1021/acs.jmedchem.3c00508 PMID: 37606563
pubmed: 37606563
doi: 10.1021/acs.jmedchem.3c00508
doi:

Substances chimiques

Amines 0
Anti-Inflammatory Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

11905-11926

Auteurs

Yongmei Tang (Y)

Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

Fanli Zheng (F)

College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 311402, China.

Xiaodong Bao (X)

Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

Yanan Zheng (Y)

College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 311402, China.

Xueping Hu (X)

Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao 266237, China.

Siyue Lou (S)

College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 311402, China.

Huajun Zhao (H)

College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou 311402, China.

Sunliang Cui (S)

Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
ORCID: 0000-0001-9407-5190

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Discovery of Highly Selective and Orally...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Discovery of Highly Selective and Orally...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Discovery of Highly Selective and Orally...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies pulmonaires › Lésion pulmonaire aigüe › Discovery of Highly Selective and Orally...
questionsmedicales.fr › Composés chimiques organiques › Amines › Discovery of Highly Selective and Orally...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Discovery of Highly Selective and Orally...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Biodisponibilité › Discovery of Highly Selective and Orally...