Peptide nucleic acid conjugates and their antimicrobial applications-a mini-review.
Aminoglycosides
Antimicrobial activity
Antisense oligonucleotides
Cell-penetrating peptides
Peptide nucleic acid (PNA)
Vitamin B12
Journal
European biophysics journal : EBJ
ISSN: 1432-1017
Titre abrégé: Eur Biophys J
Pays: Germany
ID NLM: 8409413
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
08
03
2023
accepted:
10
07
2023
revised:
07
07
2023
medline:
2
11
2023
pubmed:
23
8
2023
entrez:
23
8
2023
Statut:
ppublish
Résumé
Peptide nucleic acid (PNA) is a nucleic acid mimic with high specificity and binding affinity to natural DNA or RNA, as well as resistance to enzymatic degradation. PNA sequences can be designed to selectively silence gene expression, which makes PNA a promising tool for antimicrobial applications. However, the poor membrane permeability of PNA remains the main limiting factor for its applications in cells. To overcome this obstacle, PNA conjugates with different molecules have been developed. This mini-review focuses on covalently linked conjugates of PNA with cell-penetrating peptides, aminosugars, aminoglycoside antibiotics, and non-peptidic molecules that were tested, primarily as PNA carriers, in antibacterial and antiviral applications. The chemistries of the conjugation and the applied linkers are also discussed.
Identifiants
pubmed: 37610696
doi: 10.1007/s00249-023-01673-w
pii: 10.1007/s00249-023-01673-w
pmc: PMC10618302
doi:
Substances chimiques
Peptide Nucleic Acids
0
Anti-Bacterial Agents
0
Cell-Penetrating Peptides
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
533-544Subventions
Organisme : Narodowe Centrum Nauki
ID : UMO-2020/37/B/NZ1/02904
Informations de copyright
© 2023. The Author(s).
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