Altered G-Protein Transduction Protein Gene Expression in the Testis of Infertile Patients with Nonobstructive Azoospermia.
G-protein
Sertoli cell
azoospermia
microarray
sperm
Journal
DNA and cell biology
ISSN: 1557-7430
Titre abrégé: DNA Cell Biol
Pays: United States
ID NLM: 9004522
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
medline:
23
10
2023
pubmed:
23
8
2023
entrez:
23
8
2023
Statut:
ppublish
Résumé
Recent studies have shown that several members of the G-protein-coupled receptors (GPCR) superfamily play crucial roles in the maintenance of ion-water homeostasis of the sperm and Sertoli cells, development of the germ cells, formation of the blood barrier, and maturation of sperm. The GPCR, guanyl-nucleotide exchange factor, membrane traffic protein, and small GTPase genes were analyzed by microarray and bioinformatics (3513 sperm and Sertoli cell genes). In the microarray analyses of three human cases with different nonobstructive azoospermia sperm, the expression of
Identifiants
pubmed: 37610843
doi: 10.1089/dna.2023.0189
doi:
Substances chimiques
Monomeric GTP-Binding Proteins
EC 3.6.5.2
GTP-Binding Proteins
EC 3.6.1.-
RASA2 protein, human
0
ras GTPase-Activating Proteins
0
ANKRA2 protein, human
0
Ankyrins
0
ARL4A protein, human
EC 3.6.5.2
ADP-Ribosylation Factors
EC 3.6.5.2
RAP2A protein, human
EC 3.6.1.-
rap GTP-Binding Proteins
EC 3.6.5.2
OR2AT4 protein, human
0
RABGEF1 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM