Effects of fentanyl self-administration on risk-taking behavior in male rats.
Decision Making
Fentanyl
Flexibility
Opioid
Rats
Reward
Risk taking
Self-administration
Journal
Psychopharmacology
ISSN: 1432-2072
Titre abrégé: Psychopharmacology (Berl)
Pays: Germany
ID NLM: 7608025
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
received:
17
05
2023
accepted:
02
08
2023
medline:
13
11
2023
pubmed:
24
8
2023
entrez:
23
8
2023
Statut:
ppublish
Résumé
Individuals with opioid use disorder (OUD) exhibit impaired decision making and elevated risk-taking behavior. In contrast to the effects of natural and semi-synthetic opioids, however, the impact of synthetic opioids on decision making is still unknown. The objective of the current study was to determine how chronic exposure to the synthetic opioid fentanyl alters risk-based decision making in adult male rats. Male rats underwent 14 days of intravenous fentanyl or oral sucrose self-administration. After 3 weeks of abstinence, rats were tested in a decision-making task in which they chose between a small, safe food reward and a large food reward accompanied by variable risk of footshock punishment. Following testing in the decision-making task, rats were tested in control assays that assessed willingness to work for food and shock reactivity. Lastly, rats were tested on a probabilistic reversal learning task to evaluate enduring effects of fentanyl on behavioral flexibility. Relative to rats in the sucrose group, rats in the fentanyl group displayed greater choice of the large, risky reward (risk taking), an effect that was present as long as 7 weeks into abstinence. This increased risk taking was driven by enhanced sensitivity to the large rewards and diminished sensitivity to punishment. The fentanyl-induced elevation in risk taking was not accompanied by alterations in food motivation or shock reactivity or impairments in behavioral flexibility. Results from the current study reveal that the synthetic opioid fentanyl leads to long-lasting increases in risk taking in male rats. Future experiments will extend this work to females and identify neural mechanisms that underlie these drug-induced changes in risk taking.
Identifiants
pubmed: 37612455
doi: 10.1007/s00213-023-06447-y
pii: 10.1007/s00213-023-06447-y
doi:
Substances chimiques
Fentanyl
UF599785JZ
Analgesics, Opioid
0
Sucrose
57-50-1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2529-2544Subventions
Organisme : NIDA NIH HHS
ID : R21DA053462
Pays : United States
Organisme : NIDA NIH HHS
ID : F31DA057112
Pays : United States
Organisme : NIDA NIH HHS
ID : 5T32DA018926
Pays : United States
Organisme : NIDA NIH HHS
ID : R01DA036534
Pays : United States
Organisme : NIDA NIH HHS
ID : R21 DA053462
Pays : United States
Organisme : NIDA NIH HHS
ID : R00DA041493
Pays : United States
Organisme : NIDA NIH HHS
ID : R01DA036534
Pays : United States
Organisme : NIDA NIH HHS
ID : R00DA041493
Pays : United States
Organisme : NIDA NIH HHS
ID : R21DA053462
Pays : United States
Organisme : NIDA NIH HHS
ID : 5T32DA018926
Pays : United States
Organisme : NIDA NIH HHS
ID : F31DA057112
Pays : United States
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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