From autocatalysis to survival of the fittest in self-reproducing lipid systems.
Journal
Nature reviews. Chemistry
ISSN: 2397-3358
Titre abrégé: Nat Rev Chem
Pays: England
ID NLM: 101703631
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
accepted:
11
07
2023
medline:
9
10
2023
pubmed:
24
8
2023
entrez:
23
8
2023
Statut:
ppublish
Résumé
Studying autocatalysis - in which molecules catalyse their own formation - might help to explain the emergence of chemical systems that exhibit traits normally associated with biology. When coupled to other processes, autocatalysis can lead to complex systems-level behaviour in apparently simple mixtures. Lipids are an important class of chemicals that appear simple in isolation, but collectively show complex supramolecular and mesoscale dynamics. Here we discuss autocatalytic lipids as a source of extraordinary behaviour such as primitive chemical evolution, chemotaxis, temporally controllable materials and even as supramolecular catalysts for continuous synthesis. We survey the literature since the first examples of lipid autocatalysis and highlight state-of-the-art synthetic systems that emulate life, displaying behaviour such as metabolism and homeostasis, with special consideration for generating structural complexity and out-of-equilibrium models of life. Autocatalytic lipid systems have enormous potential for building complexity from simple components, and connections between physical effects and molecular reactivity are only just beginning to be discovered.
Identifiants
pubmed: 37612460
doi: 10.1038/s41570-023-00524-8
pii: 10.1038/s41570-023-00524-8
doi:
Substances chimiques
Lipids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
673-691Informations de copyright
© 2023. Springer Nature Limited.
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