Regulation of Presynaptic Release Machinery by Cell Adhesion Molecules.
Cadherin
Catenin
Cell adhesion molecules
Elfin
Eph receptor
Ephrin
Liquid–liquid phase separation
Neurexin
Neuroligin
Release probability
Retrograde messenger
Synaptic transmission
mGluR
Journal
Advances in neurobiology
ISSN: 2190-5215
Titre abrégé: Adv Neurobiol
Pays: United States
ID NLM: 101571545
Informations de publication
Date de publication:
2023
2023
Historique:
medline:
25
8
2023
pubmed:
24
8
2023
entrez:
24
8
2023
Statut:
ppublish
Résumé
The synapse is a highly specialized asymmetric structure that transmits and stores information in the brain. The size of pre- and postsynaptic structures and function is well coordinated at the individual synapse level. For example, large postsynaptic dendritic spines have a larger postsynaptic density with higher α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) number on their surface, while juxtaposing presynaptic terminals have a larger active zone and higher release probability. This indicates that pre- and postsynaptic domains bidirectionally communicate to coordinate assembly of specific molecules on both sides of the synaptic cleft. Cell adhesion molecules (CAMs) that localize at synapses form transsynaptic protein interactions across the synaptic cleft and play important roles in synapse formation and regulation. The extracellular domain of CAMs is essential for specific synapse formation and function. In contrast, the intracellular domain is necessary for binding with synaptic molecules and signal transduction. Therefore, CAMs play an essential role on synapse function and structure. In fact, ample evidence indicates that transsynaptic CAMs instruct and modulate functions at presynaptic sites. This chapter focuses on transsynaptic protein interactions that regulate presynaptic functions emphasizing the role of neuronal CAMs and the intracellular mechanism of their regulation.
Identifiants
pubmed: 37615873
doi: 10.1007/978-3-031-34229-5_13
doi:
Substances chimiques
Cell Adhesion Molecules
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
333-356Informations de copyright
© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.
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