Aging impairs the neurovascular interface in the heart.

Heart / innervation Microcirculation MicroRNAs / genetics Semaphorin-3A / genetics Animals Mice Aging / genetics Male Mice, Inbred C57BL Cellular Senescence / genetics Myocardium / pathology Axons Microvascular Density

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
25 08 2023
Historique:
medline: 28 8 2023
pubmed: 24 8 2023
entrez: 24 8 2023
Statut: ppublish

Résumé

Aging is a major risk factor for impaired cardiovascular health. Because the aging myocardium is characterized by microcirculatory dysfunction, and because nerves align with vessels, we assessed the impact of aging on the cardiac neurovascular interface. We report that aging reduces nerve density in the ventricle and dysregulates vascular-derived neuroregulatory genes. Aging down-regulates microRNA 145 (miR-145) and derepresses the neurorepulsive factor semaphorin-3A. miR-145 deletion, which increased

Identifiants

DOI: 10.1126/science.ade4961 PMID: 37616346
pubmed: 37616346
doi: 10.1126/science.ade4961
doi:

Substances chimiques

MicroRNAs 0
Semaphorin-3A 0
MIRN145a microRNA, mouse 0
Sema3a protein, mouse 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

897-906

Auteurs

Julian U G Wagner (JUG)

Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, 60590 Frankfurt, Germany.
Cardiopulmonary Institute (CPI), 60590 Frankfurt, Germany.
ORCID: 0000-0002-3863-854X

Lukas S Tombor (LS)

Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, 60590 Frankfurt, Germany.
Cardiopulmonary Institute (CPI), 60590 Frankfurt, Germany.
ORCID: 0000-0002-5867-576X

Pedro Felipe Malacarne (PF)

Institute for Cardiovascular Physiology, Goethe University Frankfurt, 60590 Frankfurt, Germany.

Lisa-Maria Kettenhausen (LM)

Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany.

Josefine Panthel (J)

Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany.

Haris Kujundzic (H)

Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany.

Nivethitha Manickam (N)

Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany.
Cardiopulmonary Institute (CPI), 60590 Frankfurt, Germany.

Katja Schmitz (K)

Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany.

Maria Cipca (M)

Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany.
ORCID: 0009-0003-1968-7746

Kathrin A Stilz (KA)

Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany.
ORCID: 0000-0001-7194-3231

Ariane Fischer (A)

Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany.
ORCID: 0000-0001-8074-3354

Marion Muhly-Reinholz (M)

Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany.

Wesley T Abplanalp (WT)

Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, 60590 Frankfurt, Germany.
Cardiopulmonary Institute (CPI), 60590 Frankfurt, Germany.
ORCID: 0000-0001-5996-8997

David John (D)

Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany.
ORCID: 0000-0003-3217-5449

Sarajo K Mohanta (SK)

Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München (LMU), 80336 Munich, Germany.
Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich Heart Alliance (MHA), 80802 Munich, Germany.
ORCID: 0000-0001-6144-4092

Christian Weber (C)

Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München (LMU), 80336 Munich, Germany.
Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich Heart Alliance (MHA), 80802 Munich, Germany.
Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, Netherlands.
ORCID: 0000-0003-4610-8714

Andreas J R Habenicht (AJR)

Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München (LMU), 80336 Munich, Germany.
Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich Heart Alliance (MHA), 80802 Munich, Germany.
ORCID: 0000-0003-2901-3027

Giulia K Buchmann (GK)

Institute for Cardiovascular Physiology, Goethe University Frankfurt, 60590 Frankfurt, Germany.
ORCID: 0000-0002-7266-5613

Stephan Angendohr (S)

Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.
ORCID: 0009-0002-6438-1781

Ehsan Amin (E)

Institute of Neural and Sensory Physiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.
ORCID: 0000-0003-2995-8864

Katharina Scherschel (K)

Institute of Neural and Sensory Physiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.
Division of Cardiology/Angiology/Intensive Care, EVK Düsseldorf, cNEP, cardiac Neuro- and Electrophysiology Research Consortium, 40217 Düsseldorf, Germany.
Cardiovascular Research Institute Düsseldorf (CARID), Medical Faculty and University Hospital of Düsseldorf, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.
ORCID: 0000-0002-3237-140X

Nikolaj Klöcker (N)

Institute of Neural and Sensory Physiology, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.

Malte Kelm (M)

Department of Cardiology, Pulmonology and Vascular Medicine, Medical Faculty, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.
Cardiovascular Research Institute Düsseldorf (CARID), Medical Faculty and University Hospital of Düsseldorf, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.
ORCID: 0000-0003-0060-1052

Dominik Schüttler (D)

German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich Heart Alliance (MHA), 80802 Munich, Germany.
Department of Medicine I, University Hospital Munich, Ludwig Maximilian University, 81377 Munich, Germany.
Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, LMU Munich, 81377 Munich, Germany.
Interfaculty Center for Endocrine and Cardiovascular Disease Network Modelling and Clinical Transfer (ICON), LMU Munich, 80539 Munich, Germany.
ORCID: 0000-0002-2546-5862

Sebastian Clauss (S)

German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich Heart Alliance (MHA), 80802 Munich, Germany.
Department of Medicine I, University Hospital Munich, Ludwig Maximilian University, 81377 Munich, Germany.
Institute of Surgical Research at the Walter-Brendel-Centre of Experimental Medicine, University Hospital, LMU Munich, 81377 Munich, Germany.
Interfaculty Center for Endocrine and Cardiovascular Disease Network Modelling and Clinical Transfer (ICON), LMU Munich, 80539 Munich, Germany.
ORCID: 0000-0002-5675-6128

Stefan Günther (S)

Cardiopulmonary Institute (CPI), 60590 Frankfurt, Germany.
Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.
ORCID: 0000-0002-5594-4549

Thomas Boettger (T)

German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, 60590 Frankfurt, Germany.
Cardiopulmonary Institute (CPI), 60590 Frankfurt, Germany.
Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.
ORCID: 0000-0003-4280-8449

Thomas Braun (T)

German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, 60590 Frankfurt, Germany.
Cardiopulmonary Institute (CPI), 60590 Frankfurt, Germany.
Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany.
ORCID: 0000-0002-6165-4804

Christian Bär (C)

Institute of Molecular and Translational Therapeutic Strategies (IMTTS), Hannover Medical School, 30625 Hannover, Germany.
REBIRTH-Centre for Translational Regenerative Medicine, Hannover Medical School, 30625 Hannover, Germany.

Minh-Duc Pham (MD)

Department of Medicine, Cardiology, Goethe University Hospital, 60590 Frankfurt, Germany.
Genome Biologics, 60590 Frankfurt am Main, Germany.
ORCID: 0000-0003-4880-2507

Jaya Krishnan (J)

Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany.
Cardiopulmonary Institute (CPI), 60590 Frankfurt, Germany.
Department of Medicine, Cardiology, Goethe University Hospital, 60590 Frankfurt, Germany.
ORCID: 0000-0002-5698-7671

Susanne Hille (S)

Department of Internal Medicine III, University Hospital Schleswig-Holstein, University of Kiel, 24105 Kiel, Germany.
German Centre for Cardiovascular Research (partner site Hamburg/Kiel/Lübeck), 24105 Kiel, Germany.
ORCID: 0000-0002-9809-4636

Oliver J Müller (OJ)

Department of Internal Medicine III, University Hospital Schleswig-Holstein, University of Kiel, 24105 Kiel, Germany.
German Centre for Cardiovascular Research (partner site Hamburg/Kiel/Lübeck), 24105 Kiel, Germany.
ORCID: 0000-0001-8223-2638

Tarik Bozoglu (T)

German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich Heart Alliance (MHA), 80802 Munich, Germany.
Klinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University of Munich, 81675 Munich, Germany.
ORCID: 0000-0002-6545-2150

Christian Kupatt (C)

German Center for Cardiovascular Research (DZHK), Partner Site Munich, Munich Heart Alliance (MHA), 80802 Munich, Germany.
Klinik und Poliklinik für Innere Medizin I, University Clinic rechts der Isar, Technical University of Munich, 81675 Munich, Germany.
ORCID: 0000-0002-3611-1218

Eleonora Nardini (E)

Institute of Medical Chemistry, Center for Pathobiochemistry and Genetics, Medical University of Vienna, A-1090 Vienna, Austria.
ORCID: 0000-0001-7444-0488

Selma Osmanagic-Myers (S)

Institute of Medical Chemistry, Center for Pathobiochemistry and Genetics, Medical University of Vienna, A-1090 Vienna, Austria.
ORCID: 0000-0002-3834-1332

Christian Meyer (C)

Division of Cardiology/Angiology/Intensive Care, EVK Düsseldorf, cNEP, cardiac Neuro- and Electrophysiology Research Consortium, 40217 Düsseldorf, Germany.
Cardiovascular Research Institute Düsseldorf (CARID), Medical Faculty and University Hospital of Düsseldorf, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany.
ORCID: 0000-0003-0217-3960

Andreas M Zeiher (AM)

German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, 60590 Frankfurt, Germany.
Cardiopulmonary Institute (CPI), 60590 Frankfurt, Germany.
ORCID: 0000-0003-1711-5819

Ralf P Brandes (RP)

German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, 60590 Frankfurt, Germany.
Cardiopulmonary Institute (CPI), 60590 Frankfurt, Germany.
Institute for Cardiovascular Physiology, Goethe University Frankfurt, 60590 Frankfurt, Germany.
ORCID: 0000-0002-8035-0048

Guillermo Luxán (G)

Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, 60590 Frankfurt, Germany.
Cardiopulmonary Institute (CPI), 60590 Frankfurt, Germany.
ORCID: 0000-0001-8350-8659

Stefanie Dimmeler (S)

Institute of Cardiovascular Regeneration, Centre for Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany.
German Center for Cardiovascular Research (DZHK), Partner Site Rhein-Main, 60590 Frankfurt, Germany.
Cardiopulmonary Institute (CPI), 60590 Frankfurt, Germany.
ORCID: 0000-0002-1045-2436

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Classifications MeSH

questionsmedicales.fr › Système cardiovasculaire › Coeur › Aging impairs the neurovascular interface in the heart.
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Circulation sanguine › Microcirculation › Aging impairs the neurovascular interface in the heart.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › Aging impairs the neurovascular interface in the heart.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Sémaphorines › Sémaphorine-3A › Aging impairs the neurovascular interface in the heart.
questionsmedicales.fr › Eucaryotes › Animaux › Aging impairs the neurovascular interface in the heart.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Aging impairs the neurovascular interface in the heart.
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Aging impairs the neurovascular interface in the heart.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Aging impairs the neurovascular interface in the heart.
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Vieillissement de la cellule › Aging impairs the neurovascular interface in the heart.
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Myocarde › Aging impairs the neurovascular interface in the heart.
questionsmedicales.fr › Cellules › Neurones › Neurofibres › Axones › Aging impairs the neurovascular interface in the heart.
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Densité microvasculaire › Aging impairs the neurovascular interface in the heart.