Preservation of whole antibodies within ancient teeth.

Biological sciences Paleobiochemistry Paleobiology

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
15 Sep 2023
Historique:
received: 27 04 2023
revised: 17 06 2023
accepted: 04 08 2023
medline: 25 8 2023
pubmed: 25 8 2023
entrez: 25 8 2023
Statut: epublish

Résumé

Archaeological remains can preserve some proteins into deep time, offering remarkable opportunities for probing past events in human history. Recovering functional proteins from skeletal tissues could uncover a molecular memory related to the life-history of the associated remains. We demonstrate affinity purification of whole antibody molecules from medieval human teeth, dating to the 13

Identifiants

pubmed: 37622005
doi: 10.1016/j.isci.2023.107575
pii: S2589-0042(23)01652-8
pmc: PMC10445445
doi:

Types de publication

Journal Article

Langues

eng

Pagination

107575

Informations de copyright

© 2023 The Author(s).

Déclaration de conflit d'intérêts

The authors declare no competing interests.

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Auteurs

Barry Shaw (B)

School of Life Sciences, University of Nottingham Medical School, Nottingham, UK.

Thomas McDonnell (T)

Centre for Rheumatology Research, Division of Medicine, UCL, London, UK.

Elizabeth Radley (E)

Department of Biochemistry, University of Toronto, Toronto, Canada.

Brian Thomas (B)

Mass Spectrometry Research Group, University of Liverpool, Liverpool, UK.

Lynn Smith (L)

Norton Priory Museum and Gardens, Runcorn, UK.

Carol A L Davenport (CAL)

Research Centre for Evolutionary Anthropology and Paleoecology, Liverpool John Moores University, Liverpool, UK.

Silvia Gonzalez (S)

Research Centre for Evolutionary Anthropology and Paleoecology, Liverpool John Moores University, Liverpool, UK.

Anisur Rahman (A)

Centre for Rheumatology Research, Division of Medicine, UCL, London, UK.

Rob Layfield (R)

School of Life Sciences, University of Nottingham Medical School, Nottingham, UK.

Classifications MeSH