A New Mild Method for Synthesis of Marine Alkaloid Fascaplysin and Its Therapeutically Promising Derivatives.
DNA intercalation
UV quaternization
cytotoxicity
fascaplysin derivatives
prostate cancer
synthesis
Journal
Marine drugs
ISSN: 1660-3397
Titre abrégé: Mar Drugs
Pays: Switzerland
ID NLM: 101213729
Informations de publication
Date de publication:
25 Jul 2023
25 Jul 2023
Historique:
received:
03
06
2023
revised:
09
07
2023
accepted:
21
07
2023
medline:
28
8
2023
pubmed:
25
8
2023
entrez:
25
8
2023
Statut:
epublish
Résumé
Fascaplysin is a marine alkaloid which is considered to be a lead drug candidate due to its diverse and potent biological activity. As an anticancer agent, fascaplysin holds a great potential due to the multiple targets affected by this alkaloid in cancer cells, including inhibition of cyclin-dependent kinase 4 (CDK4) and induction of intrinsic apoptosis. At the same time, the studies on structural optimization are hampered by its rather high toxicity, mainly caused by DNA intercalation. In addition, the number of methods for the syntheses of its derivatives is limited. In the current study, we report a new two-step method of synthesis of fascaplysin derivatives based on low temperature UV quaternization for the synthesis of thermolabile 9-benzyloxyfascaplysin and 6-
Identifiants
pubmed: 37623705
pii: md21080424
doi: 10.3390/md21080424
pmc: PMC10455802
pii:
doi:
Substances chimiques
fascaplysine
114719-57-2
Alkaloids
0
Antineoplastic Agents
0
Carbolines
0
DNA
9007-49-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Science and Higher Education of the Russian Federation
ID : 075-03-2022-114/7
Organisme : Russian Science Foundation
ID : № 21-14-00355
Organisme : Russian Science Foundation
ID : 22-23-01009
Organisme : Far Eastern Federal University
ID : Program FEFU Priority 2030: Physics and Materials Science
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