Novel scoring tool of hypoxemic respiratory failure and pulmonary hypertension for defining severity of persistent pulmonary hypertension of newborn.
Journal
Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
Titre abrégé: J Perinatol
Pays: United States
ID NLM: 8501884
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
22
05
2023
accepted:
21
08
2023
revised:
02
08
2023
medline:
5
10
2023
pubmed:
26
8
2023
entrez:
25
8
2023
Statut:
ppublish
Résumé
To obtain preliminary validity data for a hypoxemic respiratory failure/pulmonary hypertension (HRF/PH) score for classifying persistent pulmonary hypertension of the newborn (PPHN). Retrospective chart review of 100 consecutive neonates admitted to a Children's hospital from 2016-2021 with PPHN, gestational age ≥34 weeks, and echocardiograms in the first week. We assessed the correlation between HRF/PH score and short-term outcomes using linear and logistic regressions. HRF/PH scores ranged 2-12 (mean 8.5), and were classified mild (0-5), moderate (6-10), and severe (11-15), with 6%, 77% and 17% infants in respective categories. HRF/PH score category correlated with invasive ventilation, nitric oxide, high frequency ventilation, vasoactive infusions, extracorporeal life support and death. HRF/PH score category did not correlate with duration of support or length of stay. The HRF/PH score offers a promising representation of disease severity for PPHN. The tool requires further validation in prospective studies and evaluation for long-term outcomes.
Identifiants
pubmed: 37626160
doi: 10.1038/s41372-023-01762-w
pii: 10.1038/s41372-023-01762-w
pmc: PMC10541330
doi:
Substances chimiques
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1281-1287Subventions
Organisme : NCATS NIH HHS
ID : KL2 TR001859
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD072929
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001860
Pays : United States
Informations de copyright
© 2023. The Author(s).
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