Advanced Skeletal Ossification Is Associated with Genetic Variants in Chronologically Young Beef Heifers.
advanced skeletal maturity
beef heifers
bone
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
15 08 2023
15 08 2023
Historique:
received:
26
07
2023
revised:
08
08
2023
accepted:
09
08
2023
medline:
28
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
Osteogenesis is a developmental process critical for structural support and the establishment of a dynamic reservoir for calcium and phosphorus. Changes in livestock breeding over the past 100 years have resulted in earlier bone development and increased physical size of cattle. Advanced skeletal maturity is now commonly observed at harvest, with heifers displaying more mature bone than is expected at 30 months of age (MOA). We surmise that selection for growth traits and earlier reproductive maturity resulted in co-selection for accelerated skeletal ossification. This study examines the relationship of single nucleotide polymorphisms (SNPs) in 793 beef heifers under 30 MOA with USDA-graded skeletal maturity phenotypes (A-, B-, C- skeletal maturity). Further, the estrogen content of FDA-approved hormonal implants provided to heifers prior to harvest was evaluated in association with the identified SNPs and maturities. Association tests were performed, and the impact of the implants were evaluated as covariates against genotypes using a logistic regression model. SNPs from the
Identifiants
pubmed: 37628680
pii: genes14081629
doi: 10.3390/genes14081629
pmc: PMC10454746
pii:
doi:
Substances chimiques
Estrogens
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Références
Dev Cell. 2002 Sep;3(3):439-49
pubmed: 12361605
PLoS Genet. 2006 Dec;2(12):e216
pubmed: 17194222
Clin Orthop Relat Res. 1987 Jun;(219):237-50
pubmed: 3581576
Animal. 2014 May;8 Suppl 1:91-104
pubmed: 24698359
J Biol Chem. 2014 Dec 12;289(50):34862-70
pubmed: 25336640
Development. 2010 Mar;137(6):901-11
pubmed: 20179096
Nat Med. 2009 Mar;15(3):259-66
pubmed: 19252502
Sci Rep. 2019 Dec 30;9(1):20347
pubmed: 31889064
Emerg Med Clin North Am. 2005 Aug;23(3):703-21, viii
pubmed: 15982542
Clin J Am Soc Nephrol. 2008 Nov;3 Suppl 3:S131-9
pubmed: 18988698
Trends Endocrinol Metab. 2012 Nov;23(11):576-81
pubmed: 22595550
J Nippon Med Sch. 2010 Feb;77(1):4-12
pubmed: 20154452
J Anim Sci. 1992 Dec;70(12):3994-4005
pubmed: 1474036
Bioinformatics. 2009 Jul 15;25(14):1754-60
pubmed: 19451168
J Cell Physiol. 2008 Jan;214(1):173-82
pubmed: 17579353
J Anim Sci Biotechnol. 2020 Oct 1;11:97
pubmed: 33014361
Am J Physiol Cell Physiol. 2009 Nov;297(5):C1249-62
pubmed: 19726745
J Bone Miner Res. 2016 Oct;31(10):1888-1898
pubmed: 27128386
Nat Genet. 2018 Apr;50(4):572-580
pubmed: 29632379
Toxicol Sci. 2019 May 1;169(1):235-245
pubmed: 31059574
Mol Cell Probes. 2022 Oct;65:101850
pubmed: 35988893
Cell. 2011 Sep 16;146(6):918-30
pubmed: 21925315
Genome Res. 2010 Sep;20(9):1297-303
pubmed: 20644199
Bioinformatics. 2014 Aug 1;30(15):2114-20
pubmed: 24695404
Genes Dev. 2002 Nov 1;16(21):2813-28
pubmed: 12414734
Nat Commun. 2022 Oct 30;13(1):6491
pubmed: 36310174
Biochem Biophys Res Commun. 2018 Mar 11;497(3):908-915
pubmed: 29425818
J Endocrinol. 2014 Jun;221(3):R145-61
pubmed: 24741072
Biochem Biophys Res Commun. 1999 Nov 19;265(2):569-71
pubmed: 10558910
Proteomics. 2013 Nov;13(22):3333-53
pubmed: 24115321
Meat Sci. 2018 Jun;140:145-156
pubmed: 29571048
J Anim Sci. 2014 Apr;92(4):1792-9
pubmed: 24663159
PLoS One. 2016 Jan 20;11(1):e0147180
pubmed: 26789008
J Clin Invest. 1999 Oct;104(7):895-901
pubmed: 10510330
Anim Genet. 2021 Oct;52(5):730-733
pubmed: 34370325
J Endocrinol. 2011 Nov;211(2):109-21
pubmed: 21642379
J Anim Sci. 1992 Dec;70(12):4018-35
pubmed: 1474038
Transl Anim Sci. 2020 Feb 08;4(2):txaa017
pubmed: 32705017
Bone. 2009 May;44(5):930-5
pubmed: 19442626
Curr Opin Cell Biol. 2001 Dec;13(6):721-7
pubmed: 11698188
J Biol Chem. 2009 Jul 31;284(31):20927-35
pubmed: 19525223
FASEB J. 2012 May;26(5):1909-20
pubmed: 22278942
Cell Death Differ. 2022 Aug;29(8):1625-1638
pubmed: 35169297
Int J Mol Sci. 2021 Jan 09;22(2):
pubmed: 33435370
J Oral Maxillofac Surg. 2006 Apr;64(4):600-9
pubmed: 16546639
Int J Biol Sci. 2012;8(2):272-88
pubmed: 22298955
J Biol Chem. 2013 Nov 15;288(46):33347-60
pubmed: 24085298
Arch Biochem Biophys. 2014 Dec 15;564:173-83
pubmed: 25241053
FASEB J. 2016 Feb;30(2):635-52
pubmed: 26481310
Meat Sci. 2008 Apr;78(4):343-58
pubmed: 22062452
Int J Mol Sci. 2022 Aug 04;23(15):
pubmed: 35955807
Nat Rev Genet. 2003 Aug;4(8):638-49
pubmed: 12897775
Trends Cancer. 2016 Oct;2(10):619-631
pubmed: 28607951
Gene Expr Patterns. 2007 Jan;7(1-2):143-8
pubmed: 16904385
Calcif Tissue Int. 2016 Mar;98(3):306-15
pubmed: 26643174
J Biol Chem. 2002 Apr 19;277(16):13918-25
pubmed: 11854298
J Anim Sci. 2009 Sep;87(9):3030-42
pubmed: 19465501
Mol Biol (Mosk). 2012 Nov-Dec;46(6):846-59
pubmed: 23350231
Am J Transl Res. 2020 Aug 15;12(8):4445-4455
pubmed: 32913518
Bone. 2015 Nov;80:14-18
pubmed: 26453494
Animals (Basel). 2021 Jan 15;11(1):
pubmed: 33467455
Gene. 2020 Sep 5;754:144855
pubmed: 32522695
J Endocrinol. 2001 Nov;171(2):229-36
pubmed: 11691642
BMC Genomics. 2019 Sep 18;20(1):720
pubmed: 31533623
J Anim Sci. 2001 Jul;79(7):1683-90
pubmed: 11465354
Front Cell Dev Biol. 2020 Dec 09;8:608521
pubmed: 33363169
Cell Prolif. 2023 Aug;56(8):e13444
pubmed: 36883930
Curr Protoc Bioinformatics. 2014 Sep 08;47:11.12.1-34
pubmed: 25199790
Leukemia. 2006 Feb;20(2):224-9
pubmed: 16357831
Cell. 2001 Mar 9;104(5):719-30
pubmed: 11257226
Sci Rep. 2016 Apr 21;6:24609
pubmed: 27098880
J Anim Sci. 2006 Aug;84(8):2035-41
pubmed: 16864862
Int J Cancer. 2002 May 10;99(2):185-92
pubmed: 11979432
Transl Anim Sci. 2021 Sep 06;5(3):txab142
pubmed: 34568769
Gigascience. 2020 Mar 1;9(3):
pubmed: 32191811
Maturitas. 1996 May;23 Suppl:S65-9
pubmed: 8865143
J Anim Sci. 2004 Oct;82(10):3094-9
pubmed: 15484963
J Biol Chem. 2010 Nov 19;285(47):37111-20
pubmed: 20864534