Association of Maternal Folate Intake and Offspring MTHFD1 and MTHFD2 Genes with Congenital Heart Disease.
congenital heart defect
folic acid supplementation
interaction
methylenetetrahydrofolate dehydrogenase gene
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
09 Aug 2023
09 Aug 2023
Historique:
received:
30
06
2023
revised:
27
07
2023
accepted:
07
08
2023
medline:
28
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
Existing evidence supported that congenital heart defect (CHD) was associated with a combination of environmental and genetic factors. Based on this, this study aimed at assessing the association of maternal folic acid supplementation (FAS), genetic variations in offspring methylenetetrahydrofolate dehydrogenase (MTHFD)1 and MTHFD2 genes, and their interactions with CHD and its subtypes. A hospital-based case-control study, including 620 cases with CHD and 620 healthy children, was conducted. This study showed that the absence of FAS was significantly associated with an increased risk of total CHD and its subtypes, such as atrial septal defect (ASD). FAS during the first and second trimesters was associated with a significantly higher risk of CHD in offspring compared to FAS during the three months prior to conception. The polymorphisms of offspring MTHFD1 and MTHFD2 genes at rs2236222, rs11849530, and rs828858 were significantly associated with the risk of CHD. Additionally, a significantly positive interaction between maternal FAS and genetic variation at rs828858 was observed for the risk of CHD. These findings suggested that pregnant women should carefully consider the timing of FAS, and individuals with higher genetic risk may benefit from targeted folic acid supplementation as a preventive measure against CHD.
Identifiants
pubmed: 37630697
pii: nu15163502
doi: 10.3390/nu15163502
pmc: PMC10458540
pii:
doi:
Substances chimiques
Methylenetetrahydrofolate Dehydrogenase (NADP)
EC 1.5.1.5
Folic Acid
935E97BOY8
MTHFD1 protein, human
EC 1.5.1.5
Minor Histocompatibility Antigens
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : the National Natural Science Foundation Program of China
ID : 82073653 and 81803313
Organisme : Hunan Outstanding Youth Fund Project
ID : 2022JJ10087
Organisme : National Key Research and Development Project
ID : 2018YFE0114500
Organisme : China Postdoctoral Science Foundation
ID : 2020M682644
Organisme : Hunan Provincial Science and Technology Talent Support Project
ID : 2020TJ-N07
Organisme : Hunan Provincial Key Research and Development Program
ID : 2018SK2063
Organisme : Open Project from NHC Key Laboratory of Birth Defect for Research and Prevention
ID : KF2020006
Organisme : Natural Science Foundation of Hunan Province
ID : 2018JJ2551
Organisme : Natural Science Foundation of Hunan Province of China
ID : 2022JJ40207
Organisme : Changsha Municipal Natural Science Foundation
ID : kq2202470
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