Natural Phytochemicals as SIRT Activators-Focus on Potential Biochemical Mechanisms.
berberine
curcumin
fisetin
kaempferol
phytochemical
quercetin
resveratrol
sirtuins
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
14 Aug 2023
14 Aug 2023
Historique:
received:
14
07
2023
revised:
04
08
2023
accepted:
09
08
2023
medline:
28
8
2023
pubmed:
26
8
2023
entrez:
26
8
2023
Statut:
epublish
Résumé
Sirtuins are a family of proteins with enzymatic activity. There are seven mammalian sirtuins (SIRT1-SIRT7) that are found in different cellular compartments. They are a part of crucial cellular pathways and are regulated by many factors, such as chemicals, environmental stress, and phytochemicals. Several in vitro and in vivo studies have presented their involvement in anti-inflammatory, antioxidant, and antiapoptotic processes. Recent findings imply that phytochemicals such as resveratrol, curcumin, quercetin, fisetin, berberine, and kaempferol may regulate the activity of sirtuins. Resveratrol mainly activates SIRT1 and indirectly activates AMPK. Curcumin influences mainly SIRT1 and SIRT3, but its activity is broad, and many pathways in different cells are affected. Quercetin mainly modulates SIRT1, which triggers antioxidant and antiapoptotic responses. Fisetin, through SIRT1 regulation, modifies lipid metabolism and anti-inflammatory processes. Berberine has a wide spectrum of effects and a significant impact on SIRT1 signaling pathways. Finally, kaempferol triggers anti-inflammatory and antioxidant effects through SIRT1 induction. This review aims to summarize recent findings on the properties of phytochemicals in the modulation of sirtuin activity, with a particular focus on biochemical aspects.
Identifiants
pubmed: 37630770
pii: nu15163578
doi: 10.3390/nu15163578
pmc: PMC10459499
pii:
doi:
Substances chimiques
Berberine
0I8Y3P32UF
Antioxidants
0
Kaempferols
0
Quercetin
9IKM0I5T1E
Resveratrol
Q369O8926L
Sirtuin 1
EC 3.5.1.-
Curcumin
IT942ZTH98
Phytochemicals
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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