Non-classical circulating monocytes expressing high levels of microsomal prostaglandin E2 synthase-1 tag an aberrant IFN-response in systemic sclerosis.

CD14 Monocyte Single-cell transcriptome Systemic sclerosis scRNA-seq

Journal

Journal of autoimmunity
ISSN: 1095-9157
Titre abrégé: J Autoimmun
Pays: England
ID NLM: 8812164

Informations de publication

Date de publication:
24 Aug 2023
Historique:
received: 18 05 2023
revised: 10 08 2023
accepted: 16 08 2023
medline: 27 8 2023
pubmed: 27 8 2023
entrez: 26 8 2023
Statut: aheadofprint

Résumé

Systemic sclerosis (SSc) is a complex disease that affects the connective tissue, causing fibrosis. SSc patients show altered immune cell composition and activation in the peripheral blood (PB). PB monocytes (Mos) are recruited into tissues where they differentiate into macrophages, which are directly involved in fibrosis. To understand the role of CD14

Identifiants

DOI: 10.1016/j.jaut.2023.103097 PMID: 37633117
pubmed: 37633117
pii: S0896-8411(23)00106-3
doi: 10.1016/j.jaut.2023.103097
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

103097

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.

Auteurs

Gonzalo Villanueva-Martin (G)

Department of Cell Biology and Immunology, Institute of Parasitology and Biomedicine López-Neyra, CSIC, Granada, Spain.

Marialbert Acosta-Herrera (M)

Department of Cell Biology and Immunology, Institute of Parasitology and Biomedicine López-Neyra, CSIC, Granada, Spain; Systemic Autoimmune Disease Unit, Hospital Clínico San Cecilio, Instituto de Investigación Biosanitaria Ibs. GRANADA, Granada, Spain.

Elio G Carmona (EG)

Department of Cell Biology and Immunology, Institute of Parasitology and Biomedicine López-Neyra, CSIC, Granada, Spain; Systemic Autoimmune Disease Unit, Hospital Clínico San Cecilio, Instituto de Investigación Biosanitaria Ibs. GRANADA, Granada, Spain.

Martin Kerick (M)

Department of Cell Biology and Immunology, Institute of Parasitology and Biomedicine López-Neyra, CSIC, Granada, Spain.

Norberto Ortego-Centeno (N)

Systemic Autoimmune Disease Unit, Hospital Clínico San Cecilio, Instituto de Investigación Biosanitaria Ibs. GRANADA, Granada, Spain; Department of Medicine, University of Granada, Instituto de Investigación Biosanitaria Ibs. GRANADA, Granada, Spain.

Jose Luis Callejas-Rubio (JL)

Systemic Autoimmune Disease Unit, Hospital Clínico San Cecilio, Instituto de Investigación Biosanitaria Ibs. GRANADA, Granada, Spain.

Norbert Mages (N)

Sequencing Core Facility, Max Planck Institute for Molecular Genetics, 14195, Berlin, Germany.

Sven Klages (S)

Sequencing Core Facility, Max Planck Institute for Molecular Genetics, 14195, Berlin, Germany.

Stefan Börno (S)

Sequencing Core Facility, Max Planck Institute for Molecular Genetics, 14195, Berlin, Germany.

Bernd Timmermann (B)

Sequencing Core Facility, Max Planck Institute for Molecular Genetics, 14195, Berlin, Germany.

Lara Bossini-Castillo (L)

Department of Genetics and Biotechnology Institute, Biomedical Research Centre (CIBM), University of Granada, 18100, Granada, Spain; Advanced Therapies and Biomedical Technologies (TEC-14), Biosanitary Research Institute Ibs. GRANADA, 18016, Granada, Spain. Electronic address: lbossinicastillo@ugr.es.

Javier Martin (J)

Department of Cell Biology and Immunology, Institute of Parasitology and Biomedicine López-Neyra, CSIC, Granada, Spain. Electronic address: javiermartin@ipb.csic.es.

Classifications MeSH