Microtube embedded hydrogel bioprinting for vascularization of tissue-engineered scaffolds.
bioprinting
core-sheath electrospinning
hydrogel
microtube
vascular tissue engineering
Journal
Biotechnology and bioengineering
ISSN: 1097-0290
Titre abrégé: Biotechnol Bioeng
Pays: United States
ID NLM: 7502021
Informations de publication
Date de publication:
Dec 2023
Dec 2023
Historique:
revised:
25
07
2023
received:
08
03
2023
accepted:
19
08
2023
medline:
16
11
2023
pubmed:
28
8
2023
entrez:
28
8
2023
Statut:
ppublish
Résumé
Vascular tissue engineering has been considered promising as one of the alternatives for viable artificial tissues and organs. Macro- and microscale hollow tubes fabricated with various techniques have been widely studied to mimic blood vessels. To date, the fabrication of biomimetic capillary vessels with sizes ranging from 1 to 10 µm is still challenging. In this paper, core-sheath microtubes were electrospun to mimic capillary vessels and were embedded in carboxymethyl cellulose/sodium alginate hydrogel for bioprinting. The results showed improved printing fidelity and promoted cell attachment. The tube concentration and tube length both had significant influences on filament size and merging area. Printed groups with higher microtube concentration showed higher microtube density, with filament/nozzle size ratio, and printed/designed grid area ratio closer to 100%. In the in vitro experiments, microtubes were not only compatible with human umbilical vein endothelial cells but also provided microtopographical cues to promote cell proliferation and morphogenesis in three-dimensional space. In summary, the microtubes fabricated by our groups have the potential for the bioprinting of vascularized soft tissue scaffolds.
Substances chimiques
Hydrogels
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3592-3601Subventions
Organisme : Thomas J. Watson College of Engineering
Organisme : Applied Science at the State University of New York
Organisme : ADL Small Grant
ID : #ADL G237
Organisme : New York Empire State Development's Division of Science, Technology, and Innovation
Informations de copyright
© 2023 Wiley Periodicals LLC.
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