Toxic neuropathies.


Journal

Current opinion in neurology
ISSN: 1473-6551
Titre abrégé: Curr Opin Neurol
Pays: England
ID NLM: 9319162

Informations de publication

Date de publication:
01 10 2023
Historique:
medline: 11 9 2023
pubmed: 28 8 2023
entrez: 28 8 2023
Statut: ppublish

Résumé

Immunotherapy has had a significant impact on the treatment of an increasing number of cancers as well as in inflammatory, rheumatological and gastroenterological conditions.Recreational nitrous oxide use is now a global epidemic. Linezolid is now recommended for the treatment of drug-resistant tuberculosis (TB); neuropathy is a significant cause of morbidity.Global warming will result in increasing toxin exposure, such as ciguatera, in previously unaffected areas. With increasing experience, the pathophysiology underlying the neuropathic complications of these drugs has become clear with guidelines now available, for the complications of immune check-point inhibitors and nitrous oxide toxicity. The optimum dose and duration of treatment for resistant TB with regimens, including linezolid, has been ascertained. Although neuropathic complications with immunotherapy are relatively rare, it is essential that they are recognized and treated early. Nitrous oxide toxicity should be in the differential diagnosis for all patients, particularly those of younger age, presenting with a neuropathy or myleo-neuropathy. Ciguatera toxicity is under recognized and its geographical spread will increase due to global warming. Further research is necessary on the mechanisms and treatment of both acute and chronic effects, which at present, are only symptomatic.

Identifiants

pubmed: 37639472
doi: 10.1097/WCO.0000000000001193
pii: 00019052-990000000-00096
doi:

Substances chimiques

Linezolid ISQ9I6J12J
Nitrous Oxide K50XQU1029

Types de publication

Review Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

402-409

Subventions

Organisme : Department of Health
Pays : United Kingdom

Informations de copyright

Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

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Auteurs

Alexander M Rossor (AM)

Queen Square Centre for Neuromuscular Diseases, National Hospital for Neurology, London, UK.

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Classifications MeSH