Tet2 deletion in CD4+ T cells disrupts Th1 lineage commitment in memory cells and enhances T follicular helper cell recall responses to viral rechallenge.
T follicular helper cell
epigenetic
lineage commitment
memory T cell
viral infection
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
05 09 2023
05 09 2023
Historique:
pmc-release:
28
02
2024
medline:
31
8
2023
pubmed:
28
8
2023
entrez:
28
8
2023
Statut:
ppublish
Résumé
Following viral clearance, antigen-specific CD4+ T cells contract and form a pool of distinct Th1 and Tfh memory cells that possess unique epigenetic programs, allowing them to rapidly recall their specific effector functions upon rechallenge. DNA methylation programing mediated by the methylcytosine dioxygenase Tet2 contributes to balancing Th1 and Tfh cell differentiation during acute viral infection; however, the role of Tet2 in CD4+ T cell memory formation and recall is unclear. Using adoptive transfer models of antigen-specific wild type and
Identifiants
pubmed: 37639586
doi: 10.1073/pnas.2218324120
pmc: PMC10483640
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2218324120Subventions
Organisme : NIAID NIH HHS
ID : T32 AI138945
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI055434
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA042014
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR026802
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI137238
Pays : United States
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