DNA repair and antibody diversification: the 53BP1 paradigm.
53BP1
Igh locus architecture
V(D)J recombination
antibody diversification
class switch recombination
end-tethering
Journal
Trends in immunology
ISSN: 1471-4981
Titre abrégé: Trends Immunol
Pays: England
ID NLM: 100966032
Informations de publication
Date de publication:
10 2023
10 2023
Historique:
received:
30
06
2023
revised:
01
08
2023
accepted:
03
08
2023
medline:
2
10
2023
pubmed:
29
8
2023
entrez:
28
8
2023
Statut:
ppublish
Résumé
The DNA double-strand break (DSB) repair factor 53BP1 has long been implicated in V(D)J and class switch recombination (CSR) of mammalian lymphocyte receptors. However, the dissection of the underlying molecular activities is hampered by a paucity of studies [V(D)J] and plurality of phenotypes (CSR) associated with 53BP1 deficiency. Here, we revisit the currently accepted roles of 53BP1 in antibody diversification in view of the recent identification of its downstream effectors in DSB protection and latest advances in genome architecture. We propose that, in addition to end protection, 53BP1-mediated end-tethering stabilization is essential for CSR. Furthermore, we support a pre-DSB role during V(D)J recombination. Our perspective underscores the importance of evaluating repair of DSBs in relation to their dynamic architectural contexts.
Identifiants
pubmed: 37640588
pii: S1471-4906(23)00158-8
doi: 10.1016/j.it.2023.08.004
pii:
doi:
Substances chimiques
Antibodies
0
Tumor Suppressor p53-Binding Protein 1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
782-791Informations de copyright
Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.