High-resolution crystal structure of the Mu8.1 conotoxin from Conus mucronatus.
Mu8.1
conotoxins
hydrogen bonding
toxins
zinc binding
Journal
Acta crystallographica. Section F, Structural biology communications
ISSN: 2053-230X
Titre abrégé: Acta Crystallogr F Struct Biol Commun
Pays: United States
ID NLM: 101620319
Informations de publication
Date de publication:
01 Sep 2023
01 Sep 2023
Historique:
received:
18
06
2023
accepted:
10
08
2023
medline:
6
9
2023
pubmed:
29
8
2023
entrez:
29
8
2023
Statut:
ppublish
Résumé
Marine cone snails produce a wealth of peptide toxins (conotoxins) that bind their molecular targets with high selectivity and potency. Therefore, conotoxins constitute valuable biomolecular tools with a variety of biomedical purposes. The Mu8.1 conotoxin from Conus mucronatus is the founding member of the newly identified saposin-like conotoxin class of conotoxins and has been shown to target Cav2.3, a voltage-gated calcium channel. Two crystal structures have recently been determined of Mu8.1 at 2.3 and 2.1 Å resolution. Here, a high-resolution crystal structure of Mu8.1 was determined at 1.67 Å resolution in the high-symmetry space group I4
Identifiants
pubmed: 37642664
pii: S2053230X23007070
doi: 10.1107/S2053230X23007070
pmc: PMC10478764
doi:
Substances chimiques
Conotoxins
0
Lysine
K3Z4F929H6
Water
059QF0KO0R
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
240-246Subventions
Organisme : Teknologi og Produktion, Det Frie Forskningsråd
ID : 7017-00288
Informations de copyright
open access.
Références
Front Pharmacol. 2021 May 13;12:655981
pubmed: 34054536
Protein Sci. 1998 Aug;7(8):1700-16
pubmed: 10082367
Arch Biochem Biophys. 2003 Mar 1;411(1):112-20
pubmed: 12590929
Nat Chem. 2017 Dec;9(12):1181-1190
pubmed: 29168484
Bioessays. 2016 Jun;38(6):539-48
pubmed: 27166747
J Gen Physiol. 2012 Mar;139(3):219-34
pubmed: 22371363
J Synchrotron Radiat. 2020 Sep 1;27(Pt 5):1415-1429
pubmed: 32876619
Expert Opin Drug Discov. 2021 Oct;16(10):1163-1173
pubmed: 33914674
Nat Struct Mol Biol. 2016 Oct;23(10):916-920
pubmed: 27617429
J Phys Chem B. 2009 Mar 5;113(9):2952-60
pubmed: 19708219
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):213-21
pubmed: 20124702
PLoS Biol. 2023 Aug 3;21(8):e3002217
pubmed: 37535677
Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1743-8
pubmed: 25605914
J Chem Theory Comput. 2011 Feb 8;7(2):525-37
pubmed: 26596171
Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5260-5
pubmed: 21389271
J Biol Chem. 2019 May 31;294(22):8745-8759
pubmed: 30975904
Science. 2014 Aug 29;345(6200):1021-6
pubmed: 25103405
J Biol Chem. 1999 Dec 31;274(53):37705-8
pubmed: 10608828
Nat Protoc. 2014 Jan;9(1):156-70
pubmed: 24356774
Elife. 2019 Feb 12;8:
pubmed: 30747102
Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4085-90
pubmed: 24591597
Cell. 1981 Feb;23(2):411-22
pubmed: 7471207
Curr Biol. 2009 Jun 9;19(11):900-8
pubmed: 19481459
Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):486-501
pubmed: 20383002
Acta Crystallogr D Struct Biol. 2016 Sep;72(Pt 9):1036-48
pubmed: 27599736
J Appl Crystallogr. 2007 Aug 1;40(Pt 4):658-674
pubmed: 19461840
J Appl Crystallogr. 2009 Dec 1;42(Pt 6):1035-1042
pubmed: 22477774
J Chem Theory Comput. 2011 Jul 12;7(7):2284-95
pubmed: 26606496
J Gen Physiol. 2022 May 2;154(5):
pubmed: 35377397