FAM76B regulates NF-κB-mediated inflammatory pathway by influencing the translocation of hnRNPA2B1.
FAM76B
NF-κB pathway
cell biology
hnRNPA2B1
immunology
inflammation
mouse
neuroinflammation
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
10 08 2023
10 08 2023
Historique:
received:
19
12
2022
accepted:
09
08
2023
medline:
31
8
2023
pubmed:
29
8
2023
entrez:
29
8
2023
Statut:
epublish
Résumé
FAM76B has been reported to be a nuclear speckle-localized protein with unknown function. In this study, FAM76B was first demonstrated to inhibit the NF-κB-mediated inflammatory pathway by affecting the translocation of hnRNPA2B1 in vitro. We further showed that FAM76B suppressed inflammation in vivo using a traumatic brain injury (TBI) mouse model. Lastly, FAM76B was shown to interact with hnRNPA2B1 in human tissues taken from patients with acute, organizing, and chronic TBI, and with different neurodegenerative diseases. The results suggested that FAM76B mediated neuroinflammation via influencing the translocation of hnRNPA2B1 in vivo during TBI repair and neurodegenerative diseases. In summary, we for the first time demonstrated the role of FAM76B in regulating inflammation and further showed that FAM76B could regulate the NF-κB-mediated inflammatory pathway by affecting hnRNPA2B1 translocation, which provides new information for studying the mechanism of inflammation regulation.
Identifiants
pubmed: 37643469
doi: 10.7554/eLife.85659
pii: 85659
pmc: PMC10446823
doi:
pii:
Substances chimiques
NF-kappa B
0
FAM72B protein, human
0
hnRNP A2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023, Wang, Zheng et al.
Déclaration de conflit d'intérêts
DW, XZ, LC, JZ, JZ, YL, PY, QM, HX No competing interests declared
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