Outer Membrane Vesicle-Based Nanohybrids Target Tumor-Associated Macrophages to Enhance Trained Immunity-Related Vaccine-Generated Antitumor Activity.
antitumor mechanisms
outer membrane vesicle-based nanohybrids
trained immunity signatures
trained immunity-related vaccines (TIrV)
tumor-associated macrophages (TAMs)
Journal
Advanced materials (Deerfield Beach, Fla.)
ISSN: 1521-4095
Titre abrégé: Adv Mater
Pays: Germany
ID NLM: 9885358
Informations de publication
Date de publication:
Nov 2023
Nov 2023
Historique:
revised:
13
08
2023
received:
26
06
2023
medline:
17
11
2023
pubmed:
30
8
2023
entrez:
29
8
2023
Statut:
ppublish
Résumé
Trained immunity refers to the innate immune system building memory-like features in response to subsequent infections and vaccinations. Compared with classical tumor vaccines, trained immunity-related vaccines (TIrV) are independent of tumor-specific antigens. Bacterial outer membrane vesicles (OMVs) contain an abundance of PAMPs and have the potential to act as TIrV-inducer, but face challenges in endotoxin tolerance, systemic delivery, long-term training, and trained tumor-associated macrophage (TAM)-mediated antitumor phagocytosis. Here, an OMV-based TIrV is developed, OMV nanohybrids (OMV-SIRPα@CaP/GM-CSF) for exerting vaccine-enhanced antitumor activity. In the bone marrow, GM-CSF-assisted OMVs train bone marrow progenitor cells and monocytes, which are inherited by TAMs. In tumor tissues, SIRPα-Fc-assisted OMVs trigger TAM-mediated phagocytosis. This TIrV can be identified by metabolic and epigenetic rewiring using transposase-accessible chromatin (ATAC) and transcriptome sequencing. Furthermore, it is found that the TIrV-mediated antitumor mechanism in the MC38 tumor model (TAM-hot and T cell-cold) is trained immunity and activated T cell response, whereas in the B16-F10 tumor model (T cell-hot and TAM-cold) is primarily mediated by trained immunity. This study not only develops and identifies OMV-based TIrV, but also investigates the trained immunity signatures and therapeutic mechanisms, providing a basis for further vaccination strategies.
Identifiants
pubmed: 37643537
doi: 10.1002/adma.202306158
doi:
Substances chimiques
Granulocyte-Macrophage Colony-Stimulating Factor
83869-56-1
Cancer Vaccines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2306158Subventions
Organisme : National Key Research and Development Program of China
ID : 2022YFB3808100
Organisme : National Key Research and Development Program of China
ID : 2021YFA0909900
Organisme : Strategic Priority Research Program of the Chinese Academy of Sciences
ID : XDB36000000
Organisme : Young Scientists in Basic Research
ID : YSBR-010
Organisme : Beijing Natural Science Foundation
ID : Z200020
Organisme : National Natural Science Foundation of China
ID : T2288102
Organisme : National Natural Science Foundation of China
ID : 31820103004
Organisme : National Natural Science Foundation of China
ID : 32171384
Organisme : National Natural Science Foundation of China
ID : 32222045
Informations de copyright
© 2023 Wiley-VCH GmbH.
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