A temperature-tolerant CRISPR base editor mediates highly efficient and precise gene editing in
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
medline:
1
9
2023
pubmed:
30
8
2023
entrez:
30
8
2023
Statut:
ppublish
Résumé
CRISPR nucleases generate a broad spectrum of mutations that includes undesired editing outcomes. Here, we develop optimized C-to-T base editing systems for the generation of precise loss- or gain-of-function alleles in
Identifiants
pubmed: 37647411
doi: 10.1126/sciadv.adj1568
pmc: PMC10468138
doi:
Substances chimiques
APOBEC-1 Deaminase
EC 3.5.4.36
Cytidine Deaminase
EC 3.5.4.5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
eadj1568Références
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