ZBTB34 is a hepatocellular carcinoma-associated protein with a monopartite nuclear localization signal.
ZBTB34
hepatocellular carcinoma
importin α
nuclear localization signal
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
30 08 2023
30 08 2023
Historique:
received:
17
04
2023
accepted:
18
07
2023
medline:
7
9
2023
pubmed:
31
8
2023
entrez:
31
8
2023
Statut:
ppublish
Résumé
ZBTB34 is a novel zinc finger protein with an unknown function. In this study, the gene expression and survival prognosis of ZBTB34 were analyzed across tumors based on the TCGA datasets. According to the bioinformatics analysis and qPCR results, liver hepatocellular carcinomas exhibit a high level of ZBTB34 expression. Additionally, the experiment supported the bioinformatics analysis findings that ZBTB34 expression was regulated by miR-125b-5p and that ZBTB34 affected ZBTB10, POLR1B, and AUH expression in HepG2 cells. Biological software analysis further revealed that ZBTB34 contains a monopartite nuclear localization signal (NLS). Arginine and lysine inside the putative NLS were substituted using the alanine-scanning mutagenesis method. The findings showed that the ability of ZBTB34 to enter the nucleus was abolished by the alanine substitution of the sequence
Identifiants
pubmed: 37650557
pii: 204987
doi: 10.18632/aging.204987
pmc: PMC10496988
doi:
Substances chimiques
Nuclear Localization Signals
0
Lysine
K3Z4F929H6
Karyopherins
0
Alanine
OF5P57N2ZX
MicroRNAs
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8487-8500Références
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