A new era of macrophage-based cell therapy.
Journal
Experimental & molecular medicine
ISSN: 2092-6413
Titre abrégé: Exp Mol Med
Pays: United States
ID NLM: 9607880
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
29
03
2023
accepted:
13
06
2023
revised:
09
06
2023
medline:
4
10
2023
pubmed:
1
9
2023
entrez:
31
8
2023
Statut:
ppublish
Résumé
Macrophages are essential innate immune cells found throughout the body that have protective and pathogenic functions in many diseases. When activated, macrophages can mediate the phagocytosis of dangerous cells or materials and participate in effective tissue regeneration by providing growth factors and anti-inflammatory molecules. Ex vivo-generated macrophages have thus been used in clinical trials as cell-based therapies, and based on their intrinsic characteristics, they outperformed stem cells within specific target diseases. In addition to the old methods of generating naïve or M2 primed macrophages, the recently developed chimeric antigen receptor-macrophages revealed the potential of genetically engineered macrophages for cell therapy. Here, we review the current developmental status of macrophage-based cell therapy. The findings of important clinical and preclinical trials are updated, and patent status is investigated. Additionally, we discuss the limitations and future directions of macrophage-based cell therapy, which will help broaden the potential utility and clinical applications of macrophages.
Identifiants
pubmed: 37653035
doi: 10.1038/s12276-023-01068-z
pii: 10.1038/s12276-023-01068-z
pmc: PMC10545778
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1945-1954Informations de copyright
© 2023. The Author(s).
Références
Nat Rev Cancer. 2020 Jun;20(6):300
pubmed: 32265522
PLoS One. 2013 Jun 24;8(6):e67567
pubmed: 23826321
Nature. 2014 Oct 23;514(7523):450-4
pubmed: 25274301
Clin Exp Immunol. 2021 May;204(2):199-211
pubmed: 33426702
Annu Rev Physiol. 2017 Feb 10;79:541-566
pubmed: 27813830
Am J Respir Crit Care Med. 2018 Aug 1;198(3):297-298
pubmed: 29669215
Nat Rev Drug Discov. 2022 Sep;21(9):655-675
pubmed: 35637318
J Cell Mol Med. 2020 Mar;24(6):3314-3327
pubmed: 32004417
Sci Adv. 2020 Apr 29;6(18):eaaz6579
pubmed: 32494680
Nat Biotechnol. 2023 Feb 27;:
pubmed: 36849828
Front Immunol. 2012 Sep 26;3:297
pubmed: 23056000
Diabetes Metab Syndr Obes. 2014 Jun 23;7:211-23
pubmed: 25018643
Cancer Res. 1990 Dec 1;50(23):7450-6
pubmed: 1701343
Cell Prolif. 2021 Jun;54(6):e13050
pubmed: 33960559
Nat Biotechnol. 2016 Jul 12;34(7):677-8
pubmed: 27404861
Adv Exp Med Biol. 1990;280:287-95
pubmed: 2248150
Biomed Pharmacother. 2019 Sep;117:109178
pubmed: 31387193
J Control Release. 2016 Oct 28;240:527-540
pubmed: 27422609
Stem Cells. 2019 May;37(5):652-662
pubmed: 30720911
J Law Med Ethics. 2010 Summer;38(2):191-203
pubmed: 20579242
J Exp Med. 2008 Nov 24;205(12):2703-10
pubmed: 18955570
Cell Res. 2016 Feb;26(2):145-6
pubmed: 26768770
Nat Rev Immunol. 2008 Dec;8(12):958-69
pubmed: 19029990
Circ Res. 2014 Sep 26;115(8):730-7
pubmed: 25142002
Lancet. 2018 Mar 3;391(10123):883-910
pubmed: 28987452
J Biomed Mater Res B Appl Biomater. 2022 Jul;110(7):1637-1650
pubmed: 35113492
Stem Cells. 2021 Dec;39(12):1701-1717
pubmed: 34460131
Nat Rev Immunol. 2011 Oct 14;11(11):723-37
pubmed: 21997792
J Pathol. 2021 Mar;253(3):247-257
pubmed: 33140856
Proc Natl Acad Sci U S A. 1987 Apr;84(8):2302-6
pubmed: 2436229
Nat Rev Drug Discov. 2022 Sep;21(9):631-632
pubmed: 35650421
Br Med J. 1874 Jan 10;1(680):42-4
pubmed: 20747352
Nat Biotechnol. 2020 Dec;38(12):1387-1394
pubmed: 33273733
Sci Transl Med. 2022 Mar 16;14(636):eabl9945
pubmed: 35294256
Cell Stem Cell. 2009 Jul 2;5(1):54-63
pubmed: 19570514
Gut. 2021 Dec;70(12):2249-2260
pubmed: 33558271
J Leukoc Biol. 1998 Oct;64(4):419-26
pubmed: 9766621
Am J Respir Crit Care Med. 2010 Nov 15;182(10):1292-304
pubmed: 20622029
J Exp Med. 2020 Jul 6;217(7):
pubmed: 32357367
Sci Transl Med. 2012 Oct 10;4(155):155ra137
pubmed: 23052294
N Engl J Med. 2010 Jul 8;363(2):147-55
pubmed: 20573916
Cell Stem Cell. 2009 Mar 6;4(3):206-16
pubmed: 19265660
Nat Rev Neurosci. 2001 May;2(5):365-9
pubmed: 11331920
Exp Gerontol. 1997 Nov-Dec;32(6):633-41
pubmed: 9785089
J Immunol Methods. 1994 Sep 14;174(1-2):297-309
pubmed: 8083534
Nature. 2020 Jan;577(7790):405-409
pubmed: 31775156
Regen Med. 2013 Sep;8(5):553-67
pubmed: 23725042
Nat Med. 2019 Oct;25(10):1560-1565
pubmed: 31591593
Adv Healthc Mater. 2022 Aug;11(15):e2201178
pubmed: 35668035
Cell Rep. 2020 May 12;31(6):107643
pubmed: 32402274
Cell Transplant. 2016;25(8):1461-71
pubmed: 26671426
Basic Res Cardiol. 2019 Aug 1;114(5):34
pubmed: 31372765
N Engl J Med. 1957 Sep 12;257(11):491-6
pubmed: 13464965
Sci Am. 1991 Nov;265(5):96-102
pubmed: 1785043