Neurosteroid Receptor Modulators for Treating Traumatic Brain Injury.
Allopregnanolone
Drug therapy
Neurosteroid
Progesterone
Traumatic brain injury
Journal
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
ISSN: 1878-7479
Titre abrégé: Neurotherapeutics
Pays: United States
ID NLM: 101290381
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
accepted:
17
08
2023
medline:
30
11
2023
pubmed:
1
9
2023
entrez:
31
8
2023
Statut:
ppublish
Résumé
Traumatic brain injury (TBI) triggers wide-ranging pathology that impacts multiple biochemical and physiological systems, both inside and outside the brain. Functional recovery in patients is impeded by early onset brain edema, acute and chronic inflammation, delayed cell death, and neurovascular disruption. Drug treatments that target these deficits are under active development, but it seems likely that fully effective therapy may require interruption of the multiplicity of TBI-induced pathological processes either by a cocktail of drug treatments or a single pleiotropic drug. The complex and highly interconnected biochemical network embodied by the neurosteroid system offers multiple options for the research and development of pleiotropic drug treatments that may provide benefit for those who have suffered a TBI. This narrative review examines the neurosteroids and their signaling systems and proposes directions for their utility in the next stage of TBI drug research and development.
Identifiants
pubmed: 37653253
doi: 10.1007/s13311-023-01428-7
pii: 10.1007/s13311-023-01428-7
pmc: PMC10684848
doi:
Substances chimiques
Neurosteroids
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1603-1615Informations de copyright
© 2023. The Author(s).
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