Induction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems.

Animals Mice Immune System Aging Food, Fortified Hematopoietic Stem Cells Mitochondria

Journal

Nature aging
ISSN: 2662-8465
Titre abrégé: Nat Aging
Pays: United States
ID NLM: 101773306

Informations de publication

Date de publication:
09 2023
Historique:
received: 08 09 2021
accepted: 24 07 2023
medline: 18 9 2023
pubmed: 1 9 2023
entrez: 31 8 2023
Statut: ppublish

Résumé

Aging compromises hematopoietic and immune system functions, making older adults especially susceptible to hematopoietic failure, infections and tumor development, and thus representing an important medical target for a broad range of diseases. During aging, hematopoietic stem cells (HSCs) lose their blood reconstitution capability and commit preferentially toward the myeloid lineage (myeloid bias)

Identifiants

DOI: 10.1038/s43587-023-00473-3 PMID: 37653255
pubmed: 37653255
doi: 10.1038/s43587-023-00473-3
pii: 10.1038/s43587-023-00473-3
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1057-1066

Informations de copyright

© 2023. The Author(s), under exclusive licence to Springer Nature America, Inc.

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Auteurs

Mukul Girotra (M)

Department of Oncology, Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland.

Yi-Hsuan Chiang (YH)

Department of Oncology, Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland.
ORCID: 0009-0005-0683-0149

Melanie Charmoy (M)

Department of Oncology, University of Lausanne, Epalinges, Switzerland.

Pierpaolo Ginefra (P)

Department of Oncology, Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland.
ORCID: 0000-0003-3254-1269

Helen Carrasco Hope (HC)

Department of Oncology, Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland.
ORCID: 0000-0001-5583-4510

Charles Bataclan (C)

Laboratory of Regenerative Hematopoiesis, Department of Biomedical Sciences, University of Lausanne and ISREC, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
ORCID: 0009-0009-1880-8538

Yi-Ru Yu (YR)

Department of Oncology, Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland.
ORCID: 0000-0002-3562-3502

Frederica Schyrr (F)

Laboratory of Regenerative Hematopoiesis, Department of Biomedical Sciences, University of Lausanne and ISREC, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
ORCID: 0000-0002-9904-8316

Fabien Franco (F)

Department of Oncology, Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland.

Hartmut Geiger (H)

Institute of Molecular Medicine, Ulm University, Ulm, Germany.

Stephane Cherix (S)

Orthopedic and Traumatology Service, Lausanne University Hospital, Lausanne, Switzerland.

Ping-Chih Ho (PC)

Department of Oncology, Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland.

Olaia Naveiras (O)

Laboratory of Regenerative Hematopoiesis, Department of Biomedical Sciences, University of Lausanne and ISREC, School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Hematology Service, Department of Oncology, Lausanne University Hospital, Lausanne, Switzerland.

Johan Auwerx (J)

Laboratory of Integrative and Systems Physiology, Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
ORCID: 0000-0002-5065-5393

Werner Held (W)

Department of Oncology, University of Lausanne, Epalinges, Switzerland.

Nicola Vannini (N)

Department of Oncology, Ludwig Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland. nicola.vannini@unil.ch.
ORCID: 0000-0002-6351-7512

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Induction of mitochondrial recycling reverts...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Induction of mitochondrial recycling reverts...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Induction of mitochondrial recycling reverts...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Induction of mitochondrial recycling reverts...
questionsmedicales.fr › Aliments et boissons › Aliments › Aliment enrichi › Induction of mitochondrial recycling reverts...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système hématopoïétique › Cellules de la moelle osseuse › Cellules souches hématopoïétiques › Induction of mitochondrial recycling reverts...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Induction of mitochondrial recycling reverts...