Novel histotypes of sporadic Creutzfeldt-Jakob disease linked to 129MV genotype.
Codon 129
Histotype
Prion
Prion protein
RT-QuIC
sCJD
Journal
Acta neuropathologica communications
ISSN: 2051-5960
Titre abrégé: Acta Neuropathol Commun
Pays: England
ID NLM: 101610673
Informations de publication
Date de publication:
31 08 2023
31 08 2023
Historique:
received:
26
07
2023
accepted:
01
08
2023
medline:
4
9
2023
pubmed:
1
9
2023
entrez:
31
8
2023
Statut:
epublish
Résumé
The MV1 and MV2 subtypes of sporadic Creutzfeldt-Jakob disease (sCJD) are linked to the heterozygous methionine (M)/valine (V) polymorphism at codon 129 of the prion protein (PrP) gene. MV2 is phenotypically heterogeneous, whereas MV1, due to its low prevalence, is one of the least well characterized subtypes. In this study, we investigated the biochemical properties of PrP
Identifiants
pubmed: 37653534
doi: 10.1186/s40478-023-01631-9
pii: 10.1186/s40478-023-01631-9
pmc: PMC10469800
doi:
Substances chimiques
Prions
0
Prion Proteins
0
Types de publication
Journal Article
Research Support, U.S. Gov't, P.H.S.
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
141Subventions
Organisme : NIA NIH HHS
ID : R00 AG068359
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI106705
Pays : United States
Organisme : NIA NIH HHS
ID : K99 AG068359
Pays : United States
Informations de copyright
© 2023. BioMed Central Ltd., part of Springer Nature.
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