3D-Printed Osteoinductive Polymeric Scaffolds with Optimized Architecture to Repair a Sheep Metatarsal Critical-Size Bone Defect.
3D printing
bone tissue engineering
large animal models
medical devices
surface coatings
Journal
Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613
Informations de publication
Date de publication:
12 2023
12 2023
Historique:
revised:
10
08
2023
received:
26
05
2023
medline:
5
12
2023
pubmed:
1
9
2023
entrez:
1
9
2023
Statut:
ppublish
Résumé
The reconstruction of critical-size bone defects in long bones remains a challenge for clinicians. A new osteoinductive medical device is developed here for long bone repair by combining a 3D-printed architectured cylindrical scaffold made of clinical-grade polylactic acid (PLA) with a polyelectrolyte film coating delivering the osteogenic bone morphogenetic protein 2 (BMP-2). This film-coated scaffold is used to repair a sheep metatarsal 25-mm long critical-size bone defect. In vitro and in vivo biocompatibility of the film-coated PLA material is proved according to ISO standards. Scaffold geometry is found to influence BMP-2 incorporation. Bone regeneration is followed using X-ray scans, µCT scans, and histology. It is shown that scaffold internal geometry, notably pore shape, influenced bone regeneration, which is homogenous longitudinally. Scaffolds with cubic pores of ≈870 µm and a low BMP-2 dose of ≈120 µg cm
Identifiants
pubmed: 37655491
doi: 10.1002/adhm.202301692
doi:
Substances chimiques
Polyesters
0
Polymers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2301692Subventions
Organisme : H2020 European Research Council
ID : GA259370
Organisme : H2020 European Research Council
ID : GA692924
Organisme : H2020 European Research Council
ID : GA790435
Organisme : Union des Blessés de la Face et de la Tête
ID : 33-2022
Organisme : Agence Nationale de la Recherche
ID : ANR-18-CE17-0016
Organisme : Infrastructure d'avenir en Biologie Santé
ID : ANR-11-INBS-0006
Informations de copyright
© 2023 The Authors. Advanced Healthcare Materials published by Wiley-VCH GmbH.
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