Treatment resistance NMDA receptor pathway polygenic score is associated with brain glutamate in schizophrenia.

Humans Schizophrenia / drug therapy Glutamic Acid / metabolism Receptors, N-Methyl-D-Aspartate / genetics Brain Multifactorial Inheritance Proton Magnetic Resonance Spectroscopy Gyrus Cinguli
Glutamate anterior cingulate cortex magnetic resonance spectroscopy schizophrenia

Journal

Schizophrenia research
ISSN: 1573-2509
Titre abrégé: Schizophr Res
Pays: Netherlands
ID NLM: 8804207

Informations de publication

Date de publication:
10 2023
Historique:
received: 05 12 2022
revised: 17 08 2023
accepted: 18 08 2023
medline: 23 10 2023
pubmed: 2 9 2023
entrez: 1 9 2023
Statut: ppublish

Résumé

Dysfunction of glutamate neurotransmission has been implicated in the pathophysiology of schizophrenia and may be particularly relevant in severe, treatment-resistant symptoms. The underlying mechanism may involve hypofunction of the NMDA receptor. We investigated whether schizophrenia-related pathway polygenic scores, composed of genetic variants within NMDA receptor encoding genes, are associated with cortical glutamate in schizophrenia. Anterior cingulate cortex (ACC) glutamate was measured in 70 participants across 4 research sites using Proton Magnetic Resonance Spectroscopy (

Identifiants

DOI: 10.1016/j.schres.2023.08.020 PMID: 37657282
pubmed: 37657282
pii: S0920-9964(23)00288-8
doi: 10.1016/j.schres.2023.08.020
pii:
doi:

Substances chimiques

Glutamic Acid 3KX376GY7L
Receptors, N-Methyl-D-Aspartate 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

152-159

Subventions

Organisme : Medical Research Council
ID : MR/L011794
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest JTW is an investigator on a grant from Takeda Pharmaceuticals Ltd. to Cardiff University, for a project unrelated to the work presented here. SES is employed on this grant. GJB receives honoraria for teaching from GE Healthcare. All other authors have no conflicts of interest to disclose.

Auteurs

Kira Griffiths (K)

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, UK; NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust, London, UK.

Sophie E Smart (SE)

MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.

Gareth J Barker (GJ)

NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust, London, UK; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, UK.

Bill Deakin (B)

Division of Neuroscience and Experimental Psychology, University of Manchester, M13 9PT, UK.

Stephen M Lawrie (SM)

Division of Psychiatry, University of Edinburgh, Edinburgh, UK.

Shon Lewis (S)

Division of Psychology and Mental Health, University of Manchester, M13 9PT, UK; Greater Manchester Mental Health NHS Foundation Trust, Manchester M25 3BL, UK.

David J Lythgoe (DJ)

NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust, London, UK; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, UK.

Antonio F Pardiñas (AF)

MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.

Krishna Singh (K)

Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff CF24 4HQ, UK.

Scott Semple (S)

BHF Centre for Cardiovascular Science, University of Edinburgh, Edinburgh EH16 4TJ, UK.

James T R Walters (JTR)

MRC Centre for Neuropsychiatric Genetics and Genomics, Division of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK.

Stephen R Williams (SR)

Division of Informatics, Imaging and Data Sciences, University of Manchester, Manchester, UK.

Alice Egerton (A)

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, UK.

James H MacCabe (JH)

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, UK; NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust, London, UK. Electronic address: james.maccabe@kcl.ac.uk.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Treatment resistance NMDA receptor pathway...
questionsmedicales.fr › Troubles mentaux › Schizophrénie et troubles avec traits psychotiques › Schizophrénie › Treatment resistance NMDA receptor pathway...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés excitateurs › Acide glutamique › Treatment resistance NMDA receptor pathway...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs au glutamate › Récepteurs ionotropes du glutamate › Récepteurs du N-méthyl-D-aspartate › Treatment resistance NMDA receptor pathway...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Treatment resistance NMDA receptor pathway...
questionsmedicales.fr › Phénomènes génétiques › Modes de transmission héréditaire › Hérédité multifactorielle › Treatment resistance NMDA receptor pathway...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Spectroscopie par résonance magnétique du proton › Treatment resistance NMDA receptor pathway...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Lobe limbique › Gyrus du cingulum › Treatment resistance NMDA receptor pathway...