Taste-taste associations in chemotherapy-induced subjective taste alterations: findings from a questionnaire survey in an outpatient clinic.
Cancer
Chemotherapy
Dentistry
Dysgeusia
Taste alteration
Taste–taste association
Journal
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
ISSN: 1433-7339
Titre abrégé: Support Care Cancer
Pays: Germany
ID NLM: 9302957
Informations de publication
Date de publication:
02 Sep 2023
02 Sep 2023
Historique:
received:
10
05
2023
accepted:
22
08
2023
medline:
5
9
2023
pubmed:
4
9
2023
entrez:
2
9
2023
Statut:
epublish
Résumé
Chemotherapy-induced taste alteration is a side effect that can result in malnutrition and reduced quality of life in cancer patients. However, the underlying causes of this phenomenon remain unclear, and evidence-based treatments have not been established. This study focused on patients' subjective symptoms of taste alterations aimed to explore how the sensitivity to basic tastes changes due to anticancer agents and how alterations in one taste perception are associated with changes in other tastes during chemotherapy. A cross-sectional questionnaire-based interview survey was conducted on 215 patients undergoing chemotherapy. The subjective sensitivity to each basic taste was assessed using a visual analog scale, and the incidence of taste alterations due to different chemotherapy regimens was calculated. Multivariate logistic regression analysis was performed to determine whether there were associations between changes in one taste sensitivity and changes in other taste sensitivities. Approximately half (49.5%) of the patients experienced chemotherapy-induced taste alterations. An analysis of subjective changes in basic tastes revealed that the salt and umami taste systems were more sensitive to chemotherapy than other taste systems. Patients with altered sensitivity to sweet taste were significantly more likely to report altered sensitivity to salt, bitter, and sour tastes. Moreover, umami-salt and bitter-sour taste sensitivities were significantly related to each other. This study suggests that changes in subjective sensitivities to one basic taste during chemotherapy may be accompanied by changes in other tastes in specific combinations. Considering taste associations in dietary guidance may help improve the nutritional status of cancer patients experiencing taste alterations due to chemotherapy.
Identifiants
pubmed: 37658917
doi: 10.1007/s00520-023-08013-w
pii: 10.1007/s00520-023-08013-w
doi:
Substances chimiques
Antineoplastic Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
552Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Mosel DD, Bauer RL, Lynch DP, Hwang ST (2011) Oral complications in the treatment of cancer patients. https://doi.org/10.1111/j.1601-0825.2011.01788.x
Hovan AJ, Williams PM, Stevenson-Moore P et al (2010) A systematic review of dysgeusia induced by cancer therapies. Support Care Cancer 18:1081–1087. https://doi.org/10.1007/s00520-010-0902-1
doi: 10.1007/s00520-010-0902-1
pubmed: 20495984
Zabernigg A, Gamper E-M, Giesinger JM et al (2010) Taste alterations in cancer patients receiving chemotherapy: a neglected side effect? Oncologist 15:913–920. https://doi.org/10.1634/theoncologist.2009-0333
doi: 10.1634/theoncologist.2009-0333
pubmed: 20667968
pmcid: 3228016
Sánchez-Lara K, Sosa-Sánchez R, Green-Renner D et al (2010) Influence of taste disorders on dietary behaviors in cancer patients under chemotherapy. Nutr J 9:15. https://doi.org/10.1186/1475-2891-9-15
doi: 10.1186/1475-2891-9-15
pubmed: 20334666
pmcid: 2858711
Bernhardson BM, Tishelman C, Rutqvist LE (2007) Chemosensory changes experienced by patients undergoing cancer chemotherapy: a qualitative interview study. J Pain Symptom Manage 34:403–412. https://doi.org/10.1016/j.jpainsymman.2006.12.010
doi: 10.1016/j.jpainsymman.2006.12.010
pubmed: 17616338
Boltong A, Aranda S, Keast R et al (2014) A prospective cohort study of the effects of adjuvant breast cancer chemotherapy on taste function, food liking, appetite and associated nutritional outcomes. Plos One 9:e103512. https://doi.org/10.1371/journal.pone.0103512
doi: 10.1371/journal.pone.0103512
pubmed: 25078776
pmcid: 4117507
McLaughlin L, Mahon SM (2012) Understanding taste dysfunction in patients with cancer. Clin J Oncol Nurs 16:171–178. https://doi.org/10.1188/12.CJON.171-178
doi: 10.1188/12.CJON.171-178
pubmed: 22459526
Pellegrini M, Merlo FD, Agnello E et al (2023) Dysgeusia in patients with breast cancer treated with chemotherapy—a narrative review. Nutrients 15:226. https://doi.org/10.3390/nu15010226
doi: 10.3390/nu15010226
pubmed: 36615883
pmcid: 9823517
Rehwaldt M, Wickham R, Purl S et al (2009) Self-care strategies to cope with taste changes after chemotherapy. Oncol Nurs Forum 36:E47–E56. https://doi.org/10.1188/09.ONF.E47-E56
doi: 10.1188/09.ONF.E47-E56
pubmed: 19273394
pmcid: 2893729
Gamper EM, Zabernigg A, Wintner LM et al (2012) Coming to your senses: detecting taste and smell alterations in chemotherapy patients. A systematic review. J Pain Symptom Manage 44:880–895. https://doi.org/10.1016/j.jpainsymman.2011.11.011
doi: 10.1016/j.jpainsymman.2011.11.011
pubmed: 22921177
Sevryugin O, Kasvis P, Vigano M, Vigano A (2021) Taste and smell disturbances in cancer patients: a scoping review of available treatments. Support Care Cancer 29:49–66. https://doi.org/10.1007/s00520-020-05609-4
doi: 10.1007/s00520-020-05609-4
pubmed: 32734392
Roper SD, Chaudhari N (2017) Taste buds: cells, signals and synapses. Nat Rev Neurosci 18:485–497. https://doi.org/10.1038/nrn.2017.68
doi: 10.1038/nrn.2017.68
pubmed: 28655883
pmcid: 5958546
Bachmanov AA, Bosak NP, Lin C et al (2014) Genetics of taste receptors. Curr Pharm Des 20:2669–2683. https://doi.org/10.2174/13816128113199990566
doi: 10.2174/13816128113199990566
pubmed: 23886383
pmcid: 4764331
Lemon CH (2017) Modulation of taste processing by temperature. Am J Physiol-Regul, Integr Comp Physiol 313:R305–R321. https://doi.org/10.1152/ajpregu.00089.2017
doi: 10.1152/ajpregu.00089.2017
pubmed: 28794101
Keast RSJ, Breslin PAS (2003) An overview of binary taste-taste interactions. Food Qual Prefer 14:111–124. https://doi.org/10.1016/S0950-3293(02)00110-6
doi: 10.1016/S0950-3293(02)00110-6
Yamamoto T, Inui-Yamamoto C (2023) The flavor-enhancing action of glutamate and its mechanism involving the notion of kokumi. NPJ Sci Food 7:3. https://doi.org/10.1038/s41538-023-00178-2
doi: 10.1038/s41538-023-00178-2
pubmed: 36707516
pmcid: 9883458
Vincis R, Fontanini A (2019) Central taste anatomy and physiology. Handb Clin Neurol 164:187–204. https://doi.org/10.1016/b978-0-444-63855-7.00012-5
doi: 10.1016/b978-0-444-63855-7.00012-5
pubmed: 31604547
pmcid: 6989094
Sandri A, Cecchini MP, Riello M et al (2021) Pain, smell, and taste in adults: a narrative review of multisensory perception and interaction. Pain Ther 10:245–268. https://doi.org/10.1007/s40122-021-00247-y
doi: 10.1007/s40122-021-00247-y
pubmed: 33635507
pmcid: 8119564
Diepeveen J, Moerdijk-Poortvliet TCW, van der Leij FR (2022) Molecular insights into human taste perception and umami tastants: a review. J Food Sci 87:1449–1465. https://doi.org/10.1111/1750-3841.16101
doi: 10.1111/1750-3841.16101
pubmed: 35301715
pmcid: 9314127
Wise PM, Breslin PAS (2011) Relationships among taste qualities assessed with response-context effects. Chem Senses 36:581–587. https://doi.org/10.1093/chemse/bjr024
doi: 10.1093/chemse/bjr024
pubmed: 21441368
pmcid: 3155392
McGettigan N, Dhuibhir PU, Barrett M et al (2019) Subjective and objective assessment of taste and smell sensation in advanced cancer. Am J Hosp Palliat Med® 36:688–696. https://doi.org/10.1177/1049909119832836
doi: 10.1177/1049909119832836
Bernhardson BM, Tishelman C, Rutqvist LE (2008) Self-reported taste and smell changes during cancer chemotherapy. Support Care Cancer 16:275–283. https://doi.org/10.1007/s00520-007-0319-7
doi: 10.1007/s00520-007-0319-7
pubmed: 17710445
Nolden AA, Hwang LD, Boltong A, Reed DR (2019) Chemosensory changes from cancer treatment and their effects on patients’ food behavior: a scoping review. Nutrients 11:2285. https://doi.org/10.3390/nu11102285
doi: 10.3390/nu11102285
pubmed: 31554217
pmcid: 6836020
Chaveli-López B (2014) Oral toxicity produced by chemotherapy: a systematic review. J Clin Exp Dent 6:e81–e90. https://doi.org/10.4317/jced.51337
doi: 10.4317/jced.51337
pubmed: 24596641
pmcid: 3935911
van Bokhorst-de van der Schueren MAE (2005) Nutritional support strategies for malnourished cancer patients. Eur J Oncol Nurs 9:S74–S83. https://doi.org/10.1016/j.ejon.2005.09.004
doi: 10.1016/j.ejon.2005.09.004
pubmed: 16437760
Yamaguchi S, Ninomiya K (2000) Umami and food palatability. J Nutr 130:S921–S926. https://doi.org/10.1093/jn/130.4.921S
doi: 10.1093/jn/130.4.921S
Atsumi N, Yasumatsu K, Takashina Y et al (2023) Chloride ions evoke taste sensations by binding to the extracellular ligand-binding domain of sweet/umami taste receptors. eLife 12:e84291. https://doi.org/10.7554/eLife.84291
Obayashi N, Sakayori N, Kawaguchi H, Sugita M (2023) Effect of irinotecan administration on amiloride‐sensitive sodium taste responses in mice. Eur J Oral Sci 131:e12922. https://doi.org/10.1111/eos.12922
Shigemura N, Iwata S, Yasumatsu K et al (2013) Angiotensin II modulates salty and sweet taste sensitivities. J Neurosci 33:6267–6277. https://doi.org/10.1523/JNEUROSCI.5599-12.2013
doi: 10.1523/JNEUROSCI.5599-12.2013
pubmed: 23575826
pmcid: 6619077
Oka Y, Butnaru M, von Buchholtz L et al (2013) High salt recruits aversive taste pathways. Nature 494:472–475. https://doi.org/10.1038/nature11905
doi: 10.1038/nature11905
pubmed: 23407495
pmcid: 3587117
Chamoun E, Liu AAS, Duizer LM et al (2019) Taste sensitivity and taste preference measures are correlated in healthy young adults. Chem Senses 44:113–121. https://doi.org/10.1093/chemse/bjy082
doi: 10.1093/chemse/bjy082