Potential mechanisms of cancer-associated fibroblasts in therapeutic resistance.

Cancer-Associated Fibroblasts Drug Resistance, Neoplasm Knowledge Tumor Microenvironment Neoplasms / drug therapy
Cancer-associated fibroblasts Drug resistance

Journal

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295

Informations de publication

Date de publication:
Oct 2023
Historique:
received: 03 07 2023
revised: 30 08 2023
accepted: 30 08 2023
medline: 18 9 2023
pubmed: 4 9 2023
entrez: 3 9 2023
Statut: ppublish

Résumé

Despite continuous improvements in research and new cancer therapeutics, the goal of eradicating cancer remains elusive because of drug resistance. For a long time, drug resistance research has been focused on tumor cells themselves; however, recent studies have found that the tumor microenvironment also plays an important role in inducing drug resistance. Cancer-associated fibroblasts (CAFs) are a main component of the tumor microenvironment. They cross-talk with cancer cells to support their survival in the presence of anticancer drugs. This review summarizes the current knowledge of the role of CAFs in tumor drug resistance. An in-depth understanding of the mechanisms underlying the cross-talk between CAFs and cancer cells and insight into the importance of CAFs in drug resistance can guide the development of new anticancer strategies.

Identifiants

DOI: 10.1016/j.biopha.2023.115425 PMID: 37660643
pubmed: 37660643
pii: S0753-3322(23)01223-4
doi: 10.1016/j.biopha.2023.115425
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

115425

Informations de copyright

Copyright © 2023 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare there are no competing interests.

Auteurs

Zehua Zhao (Z)

Department of Pathology, Affiliated Cancer Hospital of Dalian University of Technology (Liaoning Cancer Hospital and Institute, Cancer Hospital of China Medical University), Shenyang, China.

Tianming Li (T)

Department of Pathology, Affiliated Cancer Hospital of Dalian University of Technology (Liaoning Cancer Hospital and Institute, Cancer Hospital of China Medical University), Shenyang, China.

Liping Sun (L)

Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, Shenyang, China; Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang, China; Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, The First Hospital of China Medical University, Shenyang, China. Electronic address: lpsun@cmu.edu.cn.

Yuan Yuan (Y)

Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, Shenyang, China; Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang, China; Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, The First Hospital of China Medical University, Shenyang, China. Electronic address: yuanyuan@cmu.edu.cn.

Yanmei Zhu (Y)

Department of Pathology, Affiliated Cancer Hospital of Dalian University of Technology (Liaoning Cancer Hospital and Institute, Cancer Hospital of China Medical University), Shenyang, China. Electronic address: zhuyanmei@cancerhosp-ln-cmu.com.

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Classifications MeSH

questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Fibroblastes associés au cancer › Potential mechanisms of cancer-associated...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance aux médicaments antinéoplasiques › Potential mechanisms of cancer-associated...
questionsmedicales.fr › Sciences humaines › Savoir › Potential mechanisms of cancer-associated...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Potential mechanisms of cancer-associated...
questionsmedicales.fr › Tumeurs › Potential mechanisms of cancer-associated...