Carbohydrate-insulin model: does the conventional view of obesity reverse cause and effect?
carbohydrate
diet
insulin
macronutrients
obesity
scientific models
Journal
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
ISSN: 1471-2970
Titre abrégé: Philos Trans R Soc Lond B Biol Sci
Pays: England
ID NLM: 7503623
Informations de publication
Date de publication:
23 10 2023
23 10 2023
Historique:
medline:
5
9
2023
pubmed:
4
9
2023
entrez:
4
9
2023
Statut:
ppublish
Résumé
Conventional obesity treatment, based on the First Law of Thermodynamics, assumes that excess body fat gain is driven by overeating, and that all calories are metabolically alike in this regard. Hence, to lose weight one must ultimately eat less and move more. However, this prescription rarely succeeds over the long term, in part because calorie restriction elicits predictable biological responses that oppose ongoing weight loss. The carbohydrate-insulin model posits the opposite causal direction:
Identifiants
pubmed: 37661740
doi: 10.1098/rstb.2022.0211
pmc: PMC10475871
doi:
Substances chimiques
Insulin
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
20220211Références
Mol Metab. 2020 May;35:100960
pubmed: 32199816
Eur J Clin Nutr. 2017 Mar;71(3):327-330
pubmed: 27901033
JAMA. 2002 May 8;287(18):2414-23
pubmed: 11988062
Nat Rev Endocrinol. 2022 May;18(5):261-262
pubmed: 35136206
Proc Nutr Soc. 2003 May;62(2):539-43
pubmed: 14506902
Dig Dis Sci. 2001 Oct;46(10):2256-62
pubmed: 11680606
Int J Obes Relat Metab Disord. 2000 Mar;24(3):288-98
pubmed: 10757621
J Neurosci. 2009 May 6;29(18):5916-25
pubmed: 19420258
Metabolism. 1992 Apr;41(4):406-14
pubmed: 1556948
Eur J Clin Nutr. 2017 Mar;71(3):323-326
pubmed: 28074888
N Engl J Med. 2008 Jul 17;359(3):229-41
pubmed: 18635428
JAMA Intern Med. 2018 Aug 1;178(8):1098-1103
pubmed: 29971406
Am J Physiol Gastrointest Liver Physiol. 2013 Jun 15;304(12):G1117-27
pubmed: 23599045
Adv Nutr. 2013 Mar 01;4(2):226-35
pubmed: 23493539
J Am Diet Assoc. 1997 Jul;97(7 Suppl):S63-9
pubmed: 9216571
BMJ. 2018 Nov 14;363:k4583
pubmed: 30429127
Lancet. 2004 Aug 28-Sep 3;364(9436):778-85
pubmed: 15337404
Mol Metab. 2014 Sep 28;3(9):823-33
pubmed: 25506548
Am J Clin Nutr. 2021 Dec 1;114(6):1873-1885
pubmed: 34515299
JAMA. 2016 Nov 22;316(20):2087-2088
pubmed: 27681384
Nat Metab. 2023 Apr;5(4):579-588
pubmed: 37100994
Obes Rev. 2021 Mar;22 Suppl 2:e13195
pubmed: 33471427
Endocr Rev. 2017 Aug 1;38(4):267-296
pubmed: 28898979
J Clin Endocrinol Metab. 2003 Jul;88(7):3082-9
pubmed: 12843147
Nutrients. 2019 Nov 12;11(11):
pubmed: 31726791
J Nutr. 2020 Aug 1;150(8):2009-2015
pubmed: 32470981
Nutr Rev. 2020 Aug 1;78(Suppl 1):69-77
pubmed: 32728757
Diabetes Obes Metab. 2017 Oct;19(10):1436-1445
pubmed: 28730694
Eur J Clin Nutr. 2022 Sep;76(9):1339-1342
pubmed: 35177807
JAMA. 2023 Jun 13;329(22):1909-1910
pubmed: 37126323
Cell Metab. 2023 May 2;35(5):737-741
pubmed: 37086719
Adv Exp Med Biol. 2021;1307:171-192
pubmed: 32077010
JAMA. 2014 Jun 4;311(21):2167-8
pubmed: 24839118
Diabetes Care. 2022 Jun 2;45(6):1303-1305
pubmed: 35653600
Am J Clin Nutr. 1995 Jul;62(1):19-29
pubmed: 7598063
J Clin Pharmacol. 2011 Dec;51(12):1620-7
pubmed: 21273395
Am J Physiol. 1997 Nov;273(5):E981-8
pubmed: 9374685
Int J Obes Relat Metab Disord. 2001 Jun;25(6):781-92
pubmed: 11439290
Clin Endocrinol Metab. 1983 Jul;12(2):359-79
pubmed: 6347450
Science. 2021 May 7;372(6542):577-578
pubmed: 33958466
N Engl J Med. 2010 Nov 25;363(22):2102-13
pubmed: 21105792
Obesity (Silver Spring). 2018 Jan;26(1):11-13
pubmed: 29265772
Diabetes Obes Metab. 2017 Oct;19(10):1446-1453
pubmed: 28741871
J Nutr. 2000 Feb;130(2S Suppl):284S-288S
pubmed: 10721889
Br J Nutr. 2016 Feb 14;115(3):466-79
pubmed: 26768850
Int J Obes (Lond). 2019 Dec;43(12):2350-2354
pubmed: 31548574
JAMA Intern Med. 2018 Aug 1;178(8):1103-1105
pubmed: 29971320
Am J Clin Nutr. 2022 Jun 7;115(6):1445-1450
pubmed: 35460220
Annu Rev Nutr. 2004;24:401-31
pubmed: 15189126
J Am Diet Assoc. 2005 May;105(5 Suppl 1):S17-23
pubmed: 15867891
Am J Clin Nutr. 2019 Sep 1;110(3):562-573
pubmed: 31347659
Am J Clin Nutr. 2013 Apr;97(4):848-53
pubmed: 23426032
BMJ. 1995 Aug 12;311(7002):437-9
pubmed: 7640595
Obesity (Silver Spring). 2014 Jul;22 Suppl 2:S41-410
pubmed: 24227637
Eur J Clin Nutr. 2020 Jul;74(7):1109-1112
pubmed: 32435054
Obesity (Silver Spring). 2022 Aug;30(8):1608-1620
pubmed: 35894080
Metabolism. 1995 Sep;44(9 Suppl 3):7-11
pubmed: 7674915
J Nutr. 2021 Mar 11;151(3):482-490
pubmed: 33274750
Gastroenterology. 2017 May;152(7):1718-1727.e3
pubmed: 28193517
J Endocr Soc. 2020 May 26;4(7):bvaa062
pubmed: 32666008
Diabetes Obes Metab. 2018 Mar;20(3):610-619
pubmed: 28941314
J Nutr. 2000 Feb;130(2S Suppl):280S-283S
pubmed: 10721888
Eur J Clin Nutr. 2022 Sep;76(9):1209-1221
pubmed: 35896818
Endocr Rev. 2018 Apr 1;39(2):79-132
pubmed: 29518206
Int J Obes (Lond). 2019 Dec;43(12):2355-2360
pubmed: 31586125
Med Clin North Am. 2018 Jan;102(1):183-197
pubmed: 29156185
N Engl J Med. 1995 Mar 9;332(10):621-8
pubmed: 7632212
Am J Clin Nutr. 2022 May 1;115(5):1243-1254
pubmed: 35134825
Pediatrics. 1999 Mar;103(3):E26
pubmed: 10049982
Lancet Diabetes Endocrinol. 2015 Dec;3(12):968-79
pubmed: 26527511
Am J Clin Nutr. 2004 May;79(5):774-9
pubmed: 15113714
Am J Physiol Endocrinol Metab. 2017 Nov 1;313(5):E608-E612
pubmed: 28765272
Nat Med. 2021 Feb;27(2):344-353
pubmed: 33479499
PLoS One. 2015 Oct 20;10(10):e0139817
pubmed: 26485706