DNA methylation patterns in CD4
CD4+ T-cell
biomarker
epigenetics
interferon
methylation
psoriasis
psoriatic arthritis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
23
06
2023
accepted:
18
07
2023
medline:
5
9
2023
pubmed:
4
9
2023
entrez:
4
9
2023
Statut:
epublish
Résumé
Psoriasis is an autoimmune/inflammatory disorder primarily affecting the skin. Chronic joint inflammation triggers the diagnosis of psoriatic arthritis (PsA) in approximately one-third of psoriasis patients. Although joint disease typically follows the onset of skin psoriasis, in around 15% of cases it is the initial presentation, which can result in diagnostic delays. The pathophysiological mechanisms underlying psoriasis and PsA are not yet fully understood, but there is evidence pointing towards epigenetic dysregulation involving CD4 The aim of this study was to investigate disease-associated DNA methylation patterns in CD4 PBMCs were collected from 12 patients with chronic plaque psoriasis and 8 PsA patients, and 8 healthy controls. CD4 Numbers and proportions of CD4 DNA methylation profiles in CD4
Sections du résumé
Background
Psoriasis is an autoimmune/inflammatory disorder primarily affecting the skin. Chronic joint inflammation triggers the diagnosis of psoriatic arthritis (PsA) in approximately one-third of psoriasis patients. Although joint disease typically follows the onset of skin psoriasis, in around 15% of cases it is the initial presentation, which can result in diagnostic delays. The pathophysiological mechanisms underlying psoriasis and PsA are not yet fully understood, but there is evidence pointing towards epigenetic dysregulation involving CD4
Objectives
The aim of this study was to investigate disease-associated DNA methylation patterns in CD4
Methods
PBMCs were collected from 12 patients with chronic plaque psoriasis and 8 PsA patients, and 8 healthy controls. CD4
Results
Numbers and proportions of CD4
Conclusion
DNA methylation profiles in CD4
Identifiants
pubmed: 37662940
doi: 10.3389/fimmu.2023.1245876
pmc: PMC10472451
doi:
Substances chimiques
Interleukin-17
0
Cyclic AMP-Dependent Protein Kinases
EC 2.7.11.11
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1245876Subventions
Organisme : Versus Arthritis
Pays : United Kingdom
Informations de copyright
Copyright © 2023 Natoli, Charras, Hofmann, Northey, Russ, Schulze, McCann, Abraham and Hedrich.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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