Id2 GABAergic interneurons comprise a neglected fourth major group of cortical inhibitory cells.


Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
04 09 2023
Historique:
received: 30 12 2022
accepted: 21 08 2023
medline: 23 10 2023
pubmed: 4 9 2023
entrez: 4 9 2023
Statut: epublish

Résumé

Cortical GABAergic interneurons (INs) represent a diverse population of mainly locally projecting cells that provide specialized forms of inhibition to pyramidal neurons and other INs. Most recent work on INs has focused on subtypes distinguished by expression of Parvalbumin (PV), Somatostatin (SST), or Vasoactive Intestinal Peptide (VIP). However, a fourth group that includes neurogliaform cells (NGFCs) has been less well characterized due to a lack of genetic tools. Here, we show that these INs can be accessed experimentally using intersectional genetics with the gene

Identifiants

pubmed: 37665123
doi: 10.7554/eLife.85893
pii: 85893
pmc: PMC10581691
doi:
pii:

Substances chimiques

Neuropeptide Y 0
Neuropeptides 0
Parvalbumins 0
Vasoactive Intestinal Peptide 37221-79-7
Idb2 protein, mouse 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIH HHS
ID : P01NS074972
Pays : United States
Organisme : NIH HHS
ID : R01NS110079
Pays : United States
Organisme : NIH HHS
ID : U19NS107616
Pays : United States

Informations de copyright

© 2023, Machold et al.

Déclaration de conflit d'intérêts

RM, SD, MV, HZ, IK, JM, JH, YH, BS, GB, BR No competing interests declared

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Auteurs

Robert Machold (R)

Neuroscience Institute, New York University Grossman School of Medicine, New York, United States.

Shlomo Dellal (S)

Neuroscience Institute, New York University Grossman School of Medicine, New York, United States.

Manuel Valero (M)

Neuroscience Institute, New York University Grossman School of Medicine, New York, United States.

Hector Zurita (H)

Neuroscience Institute, New York University Grossman School of Medicine, New York, United States.

Ilya Kruglikov (I)

Neuroscience Institute, New York University Grossman School of Medicine, New York, United States.

John Hongyu Meng (JH)

Neuroscience Institute, New York University Grossman School of Medicine, New York, United States.
Center for Neural Science, New York University, New York, United States.

Jessica L Hanson (JL)

Neuroscience Institute, New York University Grossman School of Medicine, New York, United States.

Yoshiko Hashikawa (Y)

Neuroscience Institute, New York University Grossman School of Medicine, New York, United States.

Benjamin Schuman (B)

Neuroscience Institute, New York University Grossman School of Medicine, New York, United States.

György Buzsáki (G)

Neuroscience Institute, New York University Grossman School of Medicine, New York, United States.
Department of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, United States.

Bernardo Rudy (B)

Neuroscience Institute, New York University Grossman School of Medicine, New York, United States.
Department of Neuroscience and Physiology, New York University Grossman School of Medicine, New York, United States.
Department of Anesthesiology, Perioperative Care and Pain Medicine, New York University Grossman School of Medicine, New York, United States.

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Classifications MeSH