SCH23390 and a humanized anti-cocaine mAb decrease the latency to cocaine-induced reinstatement of lever pressing behavior in rats that self-administer cocaine.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
04 09 2023
04 09 2023
Historique:
received:
25
05
2023
accepted:
24
08
2023
medline:
6
9
2023
pubmed:
5
9
2023
entrez:
4
9
2023
Statut:
epublish
Résumé
In rats that self-administer cocaine, the latency to the reinstatement of lever pressing behavior induced by a single dose of cocaine is due to the time taken for cocaine levels to fall to the satiety threshold. The D1 dopamine receptor antagonist SCH23390, and the recombinant humanized anti-cocaine mAb h2E2 increase the cocaine satiety threshold and would be expected to alter the latency to reinstatement. Male rats acquired cocaine self-administration behavior on an FR1 schedule. These rats received a single injection of cocaine (12 µmol/kg i.v.) after an i.v. injection of SCH23390 or an infusion of h2E2 or vehicle. The latency to, and the duration of, lever pressing was measured but the presses had no consequence. SCH23390 decreased the latency to lever pressing consistent with dose-dependent increases in satiety threshold. The duration of lever pressing behavior was inversely proportional to the SCH23390 dose suggesting that SCH23390 also increased the cocaine compulsion zone. The mAb h2E2 also produced a similar decrease in latency to responding that gradually reversed over 2 weeks. SCH23390 and h2E2 had an additive effect on the decreased latency to cocaine-induced lever pressing. The single cocaine dose reinstatement paradigm within the context of the compulsion zone theory is a useful pharmacological bioassay system to explore potential pharmacotherapies for relapse prevention in cocaine use disorder.
Identifiants
pubmed: 37666873
doi: 10.1038/s41598-023-41284-1
pii: 10.1038/s41598-023-41284-1
pmc: PMC10477340
doi:
Substances chimiques
SCH 23390
0
Benzazepines
0
Cocaine
I5Y540LHVR
Dopamine Antagonists
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
14566Informations de copyright
© 2023. Springer Nature Limited.
Références
de Wit, H. & Stewart, J. Reinstatement of cocaine-reinforced responding in the rat. Psychopharmacology 75, 134–143 (1981).
doi: 10.1007/BF00432175
pubmed: 6798603
Weissenborn, R., Yackey, M., Koob, G. F. & Weiss, F. Measures of cocaine-seeking behavior using a multiple schedule of food and drug self-administration in rats. Drug Alcohol Depend. 38, 237–246 (1995).
doi: 10.1016/0376-8716(95)01107-A
pubmed: 7555624
de Wit, H. & Stewart, J. Drug reinstatement of heroin-reinforced responding in the rat. Psychopharmacology 79, 29–31 (1983).
doi: 10.1007/BF00433012
pubmed: 6403961
Gerber, G. J. & Stretch, R. Drug-induced reinstatement of extinguished self-administration behavior in monkeys. Pharmacol. Biochem. Behav. 3, 1055–1061 (1975).
doi: 10.1016/0091-3057(75)90016-7
pubmed: 817297
Schenk, S., Hely, L., Gittings, D., Lake, B. & Daniela, E. Effects of priming injections of MDMA and cocaine on reinstatement of MDMA- and cocaine-seeking in rats. Drug Alcohol Depend. 96, 249–255 (2008).
doi: 10.1016/j.drugalcdep.2008.03.014
pubmed: 18472230
Stretch, R., Gerber, G. J. & Wood, S. M. Factors affecting behavior maintained by response-contingent intravenous infusions of amphetamine in squirrel monkeys. Can. J. Physiol. Pharmacol. 49, 581–589 (1971).
doi: 10.1139/y71-075
pubmed: 4996710
de Witt, H. Priming effects with drugs and other reinforcers. Exp. Clin. Psychopharmacol. 4, 5–10 (1996).
doi: 10.1037/1064-1297.4.1.5
Davis, W. M. & Smith, S. G. Role of conditioned reinforcers in the initiation, maintenance and extinction of drug-seeking behavior. Pavlov. J. Biol. Sci. 11, 222–236 (1976).
doi: 10.1007/BF03000316
pubmed: 1033507
Schenk, S. & Partridge, B. Cocaine-seeking produced by experimenter-administered drug injections: dose-effect relationships in rats. Psychopharmacology 147, 285–290 (1999).
doi: 10.1007/s002130051169
pubmed: 10639687
Spealman, R. D., Barrett-Larimore, R. L., Rowlett, J. K., Platt, D. M. & Khroyan, T. V. Pharmacological and environmental determinants of relapse to cocaine-seeking behavior. Pharmacol. Biochem. Behav. 64, 327–336 (1999).
doi: 10.1016/S0091-3057(99)00049-0
pubmed: 10515309
McFarland, K. & Kalivas, P. W. The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior. J. Neurosci. 21, 8655–8663 (2001).
doi: 10.1523/JNEUROSCI.21-21-08655.2001
pubmed: 11606653
pmcid: 6762812
Shaham, Y., Shalev, U., Lu, L., de Wit, H. & Stewart, J. The reinstatement model of drug relapse: history, methodology and major findings. Psychopharmacology 168, 3–20 (2003).
doi: 10.1007/s00213-002-1224-x
pubmed: 12402102
Zinani, D. B., Desai, J. N. & Norman, A. B. The cocaine compulsion zone theory explains the reinstatement of lever pressing behavior in rats in response to a single cocaine dose. Heliyon 9, e17988 (2023).
doi: 10.1016/j.heliyon.2023.e17988
pubmed: 37496917
pmcid: 10366394
Norman, A. B., Norman, M. K., Hall, J. F. & Tsibulsky, V. L. Priming threshold: a novel quantitative measure of the reinstatement of cocaine self-administration. Brain Res. 831, 165–174 (1999).
doi: 10.1016/S0006-8993(99)01423-7
pubmed: 10411996
Norman, A. B., Welge, J. A. & Tsibulsky, V. L. Characterization of the distribution of the cocaine priming threshold and the effect of SCH23390. Brain Res. 946, 253–261 (2002).
doi: 10.1016/S0006-8993(02)02893-7
pubmed: 12137929
Tsibulsky, V. L. & Norman, A. B. Satiety threshold: A quantitative model of maintained cocaine self-administration. Brain Res. 839, 85–93 (1999).
doi: 10.1016/S0006-8993(99)01717-5
pubmed: 10482802
Norman, A. B. & Tsibulsky, V. L. The compulsion zone: a pharmacological theory of acquired cocaine self-administration. Brain Res. 1116, 143–152 (2006).
doi: 10.1016/j.brainres.2006.07.092
pubmed: 16942754
pmcid: 2989496
Wise, R. A. et al. Fluctuations in nucleus accumbens dopamine concentration during intravenous cocaine self-administration in rats. Psychopharmacology 120, 10–20 (1995).
doi: 10.1007/BF02246140
pubmed: 7480530
Ritz, M. C., Lamb, R. J., Goldberg, S. R. & Kuhar, M. J. Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science 237, 1219–1223 (1987).
doi: 10.1126/science.2820058
pubmed: 2820058
Murnane, K. S. et al. Serotonin 2A receptors differentially contribute to abuse-related effects of cocaine and cocaine-induced nigrostriatal and mesolimbic dopamine overflow in nonhuman primates. J. Neurosci. 33, 13367–13374 (2013).
doi: 10.1523/JNEUROSCI.1437-13.2013
pubmed: 23946394
pmcid: 3742924
Rang, H. P. The receptor concept: Pharmacology’s big idea. Br. J. Pharmacol. 147, 9 (2006).
doi: 10.1038/sj.bjp.0706457
Khroyan, T. V., Platt, D. M., Rowlett, J. K. & Spealman, R. D. Attenuation of relapse to cocaine seeking by dopamine D1 receptor agonists and antagonists in non-human primates. Psychopharmacology 168, 124–131 (2003).
doi: 10.1007/s00213-002-1365-y
pubmed: 12607074
Caine, S. B. & Koob, G. F. Effects of dopamine D-1 and D-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat. J. Pharmacol. Exp. Ther. 270, 209–218 (1994).
pubmed: 8035317
Khroyan, T. V., Barrett-Larimore, R. L., Rowlett, J. K. & Spealman, R. D. Dopamine D1- and D2-like receptor mechanisms in relapse to cocaine-seeking behavior: Effects of selective antagonists and agonists. J. Pharmacol. Exp. Ther. 294, 680–687 (2000).
pubmed: 10900248
Norman, A. B., Norman, M. K., Tabet, M. R., Tsibulsky, V. L. & Pesce, A. J. Competitive dopamine receptor antagonists increase the equiactive cocaine concentration during self-administration. Synapse 65, 404–411 (2011).
doi: 10.1002/syn.20858
pubmed: 20812328
Norman, A. B., Tabet, M. R., Norman, M. K. & Tsibulsky, V. L. Using the self-administration of apomorphine and cocaine to measure the pharmacodynamic potencies and pharmacokinetics of competitive dopamine receptor antagonists. J. Neurosci. Methods 194, 252–258 (2011).
doi: 10.1016/j.jneumeth.2010.10.017
pubmed: 20974176
Wetzel, H. N., Tsibulsky, V. L. & Norman, A. B. Differential effects of acute and chronic antagonist and an irreversible antagonist treatment on cocaine self-administration behavior in rats. Sci. Rep. 12, 8782–x (2022).
doi: 10.1038/s41598-022-12798-x
pubmed: 35610298
pmcid: 9130121
Wetzel, H. N., Tsibulsky, V. L. & Norman, A. B. The effects of a repeated dose of a recombinant humanized anti-cocaine monoclonal antibody on cocaine self-administration in rats. Drug Alcohol Depend. 168, 287–292 (2016).
doi: 10.1016/j.drugalcdep.2016.09.024
pubmed: 27736682
pmcid: 5091287
Sanberg, P. R., Bunsey, M. D., Giordano, M. & Norman, A. B. The catalepsy test: its ups and downs. Behav. Neurosci. 102, 748–759 (1988).
doi: 10.1037/0735-7044.102.5.748
pubmed: 2904271
Norman, A. B., Gooden, F. C. T., Tabet, M. R. & Ball, W. J. A recombinant humanized anti-cocaine monoclonal antibody inhibits the distribution of cocaine to the brain in rats. Drug Metab. Dispos. 42, 1125–1131 (2014).
doi: 10.1124/dmd.114.057034
pubmed: 24733787
pmcid: 4053993
Norman, A. B. et al. A chimeric human/murine anticocaine monoclonal antibody inhibits the distribution of cocaine to the brain in mice. J. Pharmacol. Exp. Ther. 320, 145–153 (2007).
doi: 10.1124/jpet.106.111781
pubmed: 17023573
Robinson, T. E. & Berridge, K. C. Review. The incentive sensitization theory of addiction: some current issues. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 363, 3137–3146 (2008).
doi: 10.1098/rstb.2008.0093
pubmed: 18640920
pmcid: 2607325
Wise, R. A. Dopamine and reward: The anhedonia hypothesis 30 years on. Neurotox Res. 14, 169–183 (2008).
doi: 10.1007/BF03033808
pubmed: 19073424
pmcid: 3155128
Schultz, W. Dopamine reward prediction-error signalling: A two-component response. Nat. Rev. Neurosci. 17, 183–195 (2016).
doi: 10.1038/nrn.2015.26
pubmed: 26865020
pmcid: 5549862
Tsibulsky, V. L. & Norman, A. B. Real time computation of in vivo drug levels during drug self-administration experiments. Brain Res. Brain Res. Protoc. 15, 38–45 (2005).
doi: 10.1016/j.brainresprot.2005.03.003
pubmed: 15878149
pmcid: 3017400
Wetzel, H. N., Tabet, M. R., Ball, W. J. & Norman, A. B. The effects of a humanized recombinant anti-cocaine monoclonal antibody on the disposition of cocaethylene in mice. Int. Immunopharmacol. 23, 387–390 (2014).
doi: 10.1016/j.intimp.2014.10.025
pubmed: 25445957
pmcid: 4293271