Specific N-terminal attachment of TMTHSI linkers to native peptides and proteins for strain-promoted azide alkyne cycloaddition.

Azides Cycloaddition Reaction Peptides Antibodies Alkynes

Journal

Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838

Informations de publication

Date de publication:
21 Sep 2023
Historique:
medline: 25 9 2023
pubmed: 5 9 2023
entrez: 5 9 2023
Statut: epublish

Résumé

The site specific attachment of the reactive TMTHSI-click handle to the N-terminus of peptides and proteins is described. The resulting molecular constructs can be used in strain-promoted azide alkyne cycloaddition (SPAAC) for reaction with azide containing proteins

Identifiants

DOI: 10.1039/d3cc03397j PMID: 37668179
pubmed: 37668179
doi: 10.1039/d3cc03397j
doi:

Substances chimiques

Azides 0
Peptides 0
Antibodies 0
Alkynes 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

11397-11400

Auteurs

Matt Timmers (M)

Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht 3584 CG, The Netherlands.
Cristal Therapeutics, Maastricht 6229 EV, The Netherlands.
ORCID: 0000-0002-2176-7505

Wouter Peeters (W)

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht 6229 ER, The Netherlands.

Niels J Hauwert (NJ)

Symeres, Kerkenbos 1013, Nijmegen 6546 BB, The Netherlands.
ORCID: 0000-0002-1217-1670

Cristianne J F Rijcken (CJF)

Cristal Therapeutics, Maastricht 6229 EV, The Netherlands.

Tina Vermonden (T)

Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht 3584 CG, The Netherlands.
ORCID: 0000-0002-6047-5900

Ingrid Dijkgraaf (I)

Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht 6229 ER, The Netherlands.
ORCID: 0000-0003-4586-3646

Rob M J Liskamp (RMJ)

Cristal Therapeutics, Maastricht 6229 EV, The Netherlands.
Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht 6229 ER, The Netherlands.
School of Chemistry, University of Glasgow, Glasgow G12 8QQ, UK. robert.liskamp@glasgow.ac.uk.
ORCID: 0000-0001-8897-8975

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Azotures › Specific N-terminal attachment of TMTHSI...
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Technologie pharmaceutique › Techniques de chimie synthétique › Réaction de cycloaddition › Specific N-terminal attachment of TMTHSI...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Specific N-terminal attachment of TMTHSI...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Specific N-terminal attachment of TMTHSI...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures acycliques › Alcynes › Specific N-terminal attachment of TMTHSI...