The QseB response regulator imparts tolerance to positively charged antibiotics by controlling metabolism and minor changes to LPS.

Anti-Bacterial Agents / pharmacology Lipopolysaccharides / metabolism Escherichia coli / genetics Bacterial Proteins / genetics Lipid A Ketoglutaric Acids Polymyxin B Transcription Factors / genetics Glutamates Escherichia coli Proteins / genetics
QseB UPEC amino acid metabolism antibiotics tolerance

Journal

mSphere
ISSN: 2379-5042
Titre abrégé: mSphere
Pays: United States
ID NLM: 101674533

Informations de publication

Date de publication:
24 10 2023
Historique:
medline: 27 10 2023
pubmed: 7 9 2023
entrez: 7 9 2023
Statut: ppublish

Résumé

The modification of lipopolysaccharide (LPS) in

Identifiants

DOI: 10.1128/msphere.00059-23 PMID: 37676915 PMC: PMC10597456
pubmed: 37676915
doi: 10.1128/msphere.00059-23
pmc: PMC10597456
doi:

Substances chimiques

Anti-Bacterial Agents 0
Lipopolysaccharides 0
Bacterial Proteins 0
Lipid A 0
Ketoglutaric Acids 0
Polymyxin B J2VZ07J96K
Transcription Factors 0
Glutamates 0
QseB protein, E coli 0
Escherichia coli Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0005923

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI048689
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI107052
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI174416
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI129940
Pays : United States
Organisme : NIDDK NIH HHS
ID : P50 DK064540
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI150098
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI138576
Pays : United States
Organisme : NIDDK NIH HHS
ID : P20 DK123967
Pays : United States
Organisme : NIAID NIH HHS
ID : F31 AI143244
Pays : United States
Organisme : NIDDK NIH HHS
ID : F31 DK131902
Pays : United States
Organisme : NIAID NIH HHS
ID : F30 AI150077
Pays : United States

Commentaires et corrections

Type : UpdateOf

Déclaration de conflit d'intérêts

The authors declare no conflict of interest.

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Auteurs

Melanie N Hurst (MN)

Division of Molecular Pathogenesis, Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center , Nashville, Tennessee, USA.

Connor J Beebout (CJ)

Division of Molecular Pathogenesis, Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center , Nashville, Tennessee, USA.

Alexis Hollingsworth (A)

Department of Biological Sciences, Vanderbilt University , Nashville, Tennessee, USA.

Kirsten R Guckes (KR)

Division of Molecular Pathogenesis, Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center , Nashville, Tennessee, USA.

Alexandria Purcell (A)

Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia , Athens, Georgia, USA.

Tomas A Bermudez (TA)

Division of Molecular Pathogenesis, Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center , Nashville, Tennessee, USA.

Diamond Williams (D)

Department of Biological Sciences, Vanderbilt University , Nashville, Tennessee, USA.

Seth A Reasoner (SA)

Division of Molecular Pathogenesis, Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center , Nashville, Tennessee, USA.

M Stephen Trent (MS)

Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia , Athens, Georgia, USA.
ORCID: 0000-0001-6134-1800

Maria Hadjifrangiskou (M)

Division of Molecular Pathogenesis, Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center , Nashville, Tennessee, USA.
Vanderbilt Institute for Infection, Immunology and Inflammation , Nashville, Tennessee, USA.
Center for Personalized Microbiology, Department of Pathology, Microbiology & Immunology, Vanderbilt University Medical Center , Nashville, Tennessee, USA.
ORCID: 0000-0003-4249-8997

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › The QseB response regulator imparts tolerance...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Endotoxines › Lipopolysaccharides › The QseB response regulator imparts tolerance...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Escherichia › Escherichia coli › The QseB response regulator imparts tolerance...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › The QseB response regulator imparts tolerance...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Endotoxines › Lipopolysaccharides › Lipide A › The QseB response regulator imparts tolerance...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Cétoacides › Acides cétoglutariques › The QseB response regulator imparts tolerance...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Perforines › Peptides antimicrobiens cationiques › Polymyxines › Polymyxine B › The QseB response regulator imparts tolerance...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › The QseB response regulator imparts tolerance...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés dicarboxyliques › Glutamates › The QseB response regulator imparts tolerance...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines bactériennes › Protéines Escherichia coli › The QseB response regulator imparts tolerance...