Living liver donor pain management.
Journal
Current opinion in organ transplantation
ISSN: 1531-7013
Titre abrégé: Curr Opin Organ Transplant
Pays: United States
ID NLM: 9717388
Informations de publication
Date de publication:
01 12 2023
01 12 2023
Historique:
medline:
2
11
2023
pubmed:
8
9
2023
entrez:
7
9
2023
Statut:
ppublish
Résumé
Optimal pain control in living liver donors undergoing hepatectomy is strongly recommended considering their unique status as healthy individuals willingly undergoing surgery for the benefit of the recipient. This review aims to examine and evaluate different strategies aimed at ensuring effective postoperative pain management in living liver donors. Enhanced recovery after surgery (ERAS) protocols have proven effective in optimizing patient outcomes, including in living liver donor hepatectomy. By implementing these protocols, healthcare professionals can enhance postoperative pain control and accelerate recovery. Multimodal analgesia, which combines different techniques and agents, is crucial in pain management for living liver donors. Regional analgesia techniques, such as spinal anesthesia and various peripheral nerve blocks, have shown efficacy in reducing pain and facilitating early recovery. Systemic nonopioid analgesics, including acetaminophen, nonsteroidal anti-inflammatory drugs, ketamine, lidocaine, and dexmedetomidine act synergistically to alleviate pain and reduce inflammation. Minimizing the use of opioids is important to avoid adverse effects, and they should be reserved for rescue medication or breakthrough pain. Applying the principles of ERAS and multimodal analgesia to living liver donors can effectively control pain while promoting early recovery.
Identifiants
pubmed: 37678396
doi: 10.1097/MOT.0000000000001099
pii: 00075200-202312000-00002
doi:
Substances chimiques
Acetaminophen
362O9ITL9D
Lidocaine
98PI200987
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
391-396Informations de copyright
Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
Références
Khalil A, Ganesh S, Hughes C, et al. Evaluation of the enhanced recovery after surgery protocol in living liver donors. Clin Transplant 2018; 32:e13342.
Krenn CG, Faybik P, Hetz H. Living-related liver transplantation: implication for the anaesthetist. Curr Opin Anaesthesiol 2004; 17:285–290.
Holtzman S, Clarke HA, McCluskey SA, et al. Acute and chronic postsurgical pain after living liver donation: incidence and predictors. Liver Transpl 2014; 20:1336–1346.
Mandell MS, Smith AR, Dew MA, et al. Early postoperative pain and its predictors in the Adult to Adult Living Donor Liver Transplantation Cohort Study. Transplantation 2016; 100:2362–2371.
Butt Z, DiMartini AF, Liu Q, et al. Fatigue, pain, and other physical symptoms of living liver donors in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study. Liver Transpl 2018; 24:1221–1232.
Mandell MS, Huang J, Zhao J. Enhanced recovery after surgery and practical application to liver transplantation. Best Pract Res Clin Anaesthesiol 2020; 34:119–127.
Hardman MI, Olsen DA, Amundson AW. Multimodal analgesia decreases postoperative opioid consumption in living liver donation. Mayo Clin Proc Innov Qual Outcomes 2021; 5:583–589.
Hendrickse A, Ko J, Sakai T. The care of donors and recipients in adult living donor liver transplantation. BJA Educ 2022; 22:387–395.
Hogan BJ, Pai SL, Planinsic R, et al. Does multimodal perioperative pain management enhance immediate and short-term outcomes after living donor partial hepatectomy? A systematic review of the literature and expert panel recommendations. Clin Transplant 2022; 36:e14649.
Sakai T, Ko JS, Crouch CE, et al. Perioperative management of living donor liver transplantation: Part 2 - Donors. Clin Transplant 2022; 36:e14690.
Choi SJ, Gwak MS, Ko JS, et al. The changes in coagulation profile and epidural catheter safety for living liver donors: a report on 6 years of our experience. Liver Transpl 2007; 13:62–70.
Koul A, Pant D, Rudravaram S, Sood J. Thoracic epidural analgesia in donor hepatectomy: an analysis. Liver Transpl 2018; 24:214–221.
Clarke H, Chandy T, Srinivas C, et al. Epidural analgesia provides better pain management after live liver donation: a retrospective study. Liver Transpl 2011; 17:315–323.
Ko JS, Choi SJ, Gwak MS, et al. Intrathecal morphine combined with intravenous patient-controlled analgesia is an effective and safe method for immediate postoperative pain control in live liver donors. Liver Transpl 2009; 15:381–389.
Chan SK, Lai PB, Li PT, et al. The analgesic efficacy of continuous wound instillation with ropivacaine after open hepatic surgery. Anaesthesia 2010; 65:1180–1186.
Lee SH, Gwak MS, Choi SJ, et al. Prospective, randomized study of ropivacaine wound infusion versus intrathecal morphine with intravenous fentanyl for analgesia in living donors for liver transplantation. Liver Transpl 2013; 19:1036–1045.
Maeda A, Shibata SC, Wada H, et al. The efficacy of continuous subcostal transversus abdominis plane block for analgesia after living liver donation: a retrospective study. J Anesth 2016; 30:39–46.
Erdogan MA, Ozgul U, Ucar M, et al. Effect of transversus abdominis plane block in combination with general anesthesia on perioperative opioid consumption, hemodynamics, and recovery in living liver donors: the prospective, double-blinded, randomized study. Clin Transplant 2017; 31:e12931.
Kitlik A, Erdogan MA, Ozgul U, et al. Ultrasound-guided transversus abdominis plane block for postoperative analgesia in living liver donors: a prospective, randomized, double-blinded clinical trial. J Clin Anesth 2017; 37:103–107.
Khan J, Katz J, Montbriand J, et al. Surgically placed abdominal wall catheters on postoperative analgesia and outcomes after living liver donation. Liver Transpl 2015; 21:478–486.
Amundson AW, Olsen DA, Smith HM, et al. Acute benefits after liposomal bupivacaine abdominal wall blockade for living liver donation: a retrospective review. Mayo Clin Proc Innov Qual Outcomes 2018; 2:186–193.
Kang R, Chin KJ, Gwak MS, et al. Bilateral single-injection erector spinae plane block versus intrathecal morphine for postoperative analgesia in living donor laparoscopic hepatectomy: a randomized noninferiority trial. Reg Anesth Pain Med 2019; 44:1059–1065.
Kang R, Chin KJ, Kim GS, et al. Bilateral continuous erector spinae plane block using a programmed intermittent bolus regimen versus intrathecal morphine for postoperative analgesia in living donor laparoscopic hepatectomy: a randomized controlled trial. J Clin Anesth 2021; 75:110479.
Lee S, Kang RA, Kim GS, et al. Comparison of postoperative analgesic effects of posterior quadratus lumborum block and intrathecal morphine in laparoscopic donor hepatectomy: a prospective randomized noninferiority clinical trial. Reg Anesth Pain Med 2022; 47:527–533.
Lim KI, Liu CK, Chen CL, et al. Transitional study of patient-controlled analgesia morphine with ketorolac to patient-controlled analgesia morphine with parecoxib among donors in adult living donor liver transplantation: a single-center experience. Transplant Proc 2016; 48:1074–1076.
Halaszynski TM, Dai F, Huang Y. Donor hepatectomy surgery using ketamine to compliment analgesia and reduce morbidity: a retrospective chart review investigation. Turk J Anaesthesiol Reanim 2018; 46:28–37.
Tseng WC, Lin WL, Lai HC, et al. Adjunctive dexmedetomidine infusion in open living donor hepatectomy: a way to enhance postoperative analgesia and recovery. Int J Clin Pract 2021; 75:e14002.
Joliat GR, Kobayashi K, Hasegawa K, et al. Guidelines for perioperative care for liver surgery: Enhanced Recovery After Surgery (ERAS) Society Recommendations. World J Surg 2023; 47:11–34.
Siniscalchi A, Begliomini B, De Pietri L, et al. Increased prothrombin time and platelet counts in living donor right hepatectomy: implications for epidural anesthesia. Liver Transpl 2004; 10:1144–1149.
Cammu G, Troisi R, Cuomo O, et al. Anaesthetic management and outcome in right-lobe living liver-donor surgery. Eur J Anaesthesiol 2002; 19:93–98.
Akpek EA, Arslan G, Erkaya C, et al. Anesthetic risks for donors in living-related liver transplantation: analysis of 30 cases. Transpl Int 2003; 16:486–490.
Tsui SL, Yong BH, Ng KF, et al. Delayed epidural catheter removal: the impact of postoperative coagulopathy. Anaesth Intensive Care 2004; 32:630–636.
Vandermeulen EP, Van Aken H, Vermylen J. Anticoagulants and spinal-epidural anesthesia. Anesth Analg 1994; 79:1165–1177.
Horlocker TT, Wedel DJ, Benzon H, et al. Regional anesthesia in the anticoagulated patient: defining the risks (the second ASRA Consensus Conference on Neuraxial Anesthesia and Anticoagulation). Reg Anesth Pain Med 2003; 28:172–197.
Wang JK, Nauss LA, Thomas JE. Pain relief by intrathecally applied morphine in man. Anesthesiology 1979; 50:149–151.
Roy JD, Massicotte L, Sassine MP, et al. A comparison of intrathecal morphine/fentanyl and patient-controlled analgesia with patient-controlled analgesia alone for analgesia after liver resection. Anesth Analg 2006; 103:990–994.
Tang JZJ, Weinberg L. A literature review of intrathecal morphine analgesia in patients undergoing major open hepato-pancreatic-biliary (HPB) surgery. Anesth Pain Med 2019; 9:e94441.
Ready LB. Acute pain: lessons learned from 25,000 patients. Reg Anesth Pain Med 1999; 24:499–505.
Horlocker TT, Wedel DJ, Schroeder DR, et al. Preoperative antiplatelet therapy does not increase the risk of spinal hematoma associated with regional anesthesia. Anesth Analg 1995; 80:303–309.
Koning MV, Klimek M, Rijs K, et al. Intrathecal hydrophilic opioids for abdominal surgery: a meta-analysis, meta-regression, and trial sequential analysis. Br J Anaesth 2020; 125:358–372.
Jeong JS, Wi W, Chung YJ, et al. Comparison of perioperative outcomes between pure laparoscopic surgery and open right hepatectomy in living donor hepatectomy: propensity score matching analysis. Sci Rep 2020; 10:5314.
Lee S, Kang R, Choi GS, et al. Comparison of two doses of intrathecal morphine in laparoscopic donor hepatectomy: a randomized double-blinded noninferiority trial. Clin Transplant 2023; 37:e14996.
El-Dawlatly AA, Turkistani A, Kettner SC, et al. Ultrasound-guided transversus abdominis plane block: description of a new technique and comparison with conventional systemic analgesia during laparoscopic cholecystectomy. Br J Anaesth 2009; 102:763–767.
Hebbard PD, Barrington MJ, Vasey C. Ultrasound-guided continuous oblique subcostal transversus abdominis plane blockade: description of anatomy and clinical technique. Reg Anesth Pain Med 2010; 35:436–441.
Johns N, O’Neill S, Ventham NT, et al. Clinical effectiveness of transversus abdominis plane (TAP) block in abdominal surgery: a systematic review and meta-analysis. Colorectal Dis 2012; 14:e635–642.
De Oliveira GS Jr, Castro-Alves LJ, Nader A, et al. Transversus abdominis plane block to ameliorate postoperative pain outcomes after laparoscopic surgery: a meta-analysis of randomized controlled trials. Anesth Analg 2014; 118:454–463.
Chin KJ, Adhikary S, Sarwani N, Forero M. The analgesic efficacy of preoperative bilateral erector spinae plane (ESP) blocks in patients having ventral hernia repair. Anaesthesia 2017; 72:452–460.
Chin KJ, Malhas L, Perlas A. The erector spinae plane block provides visceral abdominal analgesia in bariatric surgery: a report of 3 cases. Reg Anesth Pain Med 2017; 42:372–376.
Hacibeyoglu G, Topal A, Arican S, et al. USG guided bilateral erector spinae plane block is an effective and safe postoperative analgesia method for living donor liver transplantation. J Clin Anesth 2018; 49:36–37.
Adhikary SD, Bernard S, Lopez H, Chin KJ. Erector spinae plane block versus retrolaminar block: a magnetic resonance imaging and anatomical study. Reg Anesth Pain Med 2018; 43:756–762.
Schwartzmann A, Peng P, Maciel MA, Forero M. Mechanism of the erector spinae plane block: insights from a magnetic resonance imaging study. Can J Anaesth 2018; 65:1165–1166.
Ivanusic J, Konishi Y, Barrington MJ. A cadaveric study investigating the mechanism of action of erector spinae blockade. Reg Anesth Pain Med 2018; 43:567–571.
Aponte A, Sala-Blanch X, Prats-Galino A, et al. Anatomical evaluation of the extent of spread in the erector spinae plane block: a cadaveric study. Can J Anaesth 2019; 66:886–893.
Gurkan Y, Aksu C, Kus A, et al. Ultrasound guided erector spinae plane block reduces postoperative opioid consumption following breast surgery: a randomized controlled study. J Clin Anesth 2018; 50:65–68.
Abu Elyazed MM, Mostafa SF, Abdelghany MS, Eid GM. Ultrasound-guided erector spinae plane block in patients undergoing open epigastric hernia repair: a prospective randomized controlled study. Anesth Analg 2019; 129:235–240.
Elsharkawy H, El-Boghdadly K, Barrington M. Quadratus lumborum block: anatomical concepts, mechanisms, and techniques. Anesthesiology 2019; 130:322–335.
Pang M, Sun G, Yao W, et al. Ultrasound-guided transmuscular quadratus lumborum block reduced postoperative opioids consumptions in patients after laparoscopic hepatectomy: a three-arm randomized controlled trial. BMC Anesthesiol 2021; 21:45.
Kang R, Lee S, Kim GS, et al. Comparison of analgesic efficacy of erector spinae plane block and posterior quadratus lumborum block in laparoscopic liver resection: a randomized controlled trial. J Pain Res 2021; 14:3791–3800.