GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.

Humans Glucose Genome-Wide Association Study Blood Glucose / genetics Diabetes Mellitus, Type 2 / genetics Colon

Journal

Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904

Informations de publication

Date de publication:
09 2023
Historique:
received: 18 09 2021
accepted: 27 06 2023
medline: 11 9 2023
pubmed: 8 9 2023
entrez: 7 9 2023
Statut: ppublish

Résumé

Conventional measurements of fasting and postprandial blood glucose levels investigated in genome-wide association studies (GWAS) cannot capture the effects of DNA variability on 'around the clock' glucoregulatory processes. Here we show that GWAS meta-analysis of glucose measurements under nonstandardized conditions (random glucose (RG)) in 476,326 individuals of diverse ancestries and without diabetes enables locus discovery and innovative pathophysiological observations. We discovered 120 RG loci represented by 150 distinct signals, including 13 with sex-dimorphic effects, two cross-ancestry and seven rare frequency signals. Of these, 44 loci are new for glycemic traits. Regulatory, glycosylation and metagenomic annotations highlight ileum and colon tissues, indicating an underappreciated role of the gastrointestinal tract in controlling blood glucose. Functional follow-up and molecular dynamics simulations of lower frequency coding variants in glucagon-like peptide-1 receptor (GLP1R), a type 2 diabetes treatment target, reveal that optimal selection of GLP-1R agonist therapy will benefit from tailored genetic stratification. We also provide evidence from Mendelian randomization that lung function is modulated by blood glucose and that pulmonary dysfunction is a diabetes complication. Our investigation yields new insights into the biology of glucose regulation, diabetes complications and pathways for treatment stratification.

Identifiants

DOI: 10.1038/s41588-023-01462-3 PMID: 37679419 PMC: PMC10484788
pubmed: 37679419
doi: 10.1038/s41588-023-01462-3
pii: 10.1038/s41588-023-01462-3
pmc: PMC10484788
doi:

Substances chimiques

Glucose IY9XDZ35W2
Blood Glucose 0

Types de publication

Meta-Analysis Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1448-1461

Subventions

Organisme : Medical Research Council
ID : MC_UU_00006/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : CH/1992001/6764
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N003284/1
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : U01 DK105535
Pays : United States
Organisme : British Heart Foundation
ID : SP/19/2/34462
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R010676/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M009203/1
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_14089
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_EX_MR/M009203/1
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : R01 DK072193
Pays : United States

Investigateurs

Marcel den Hoed (M)
Cornelia M van Duijn (CM)

Informations de copyright

© 2023. The Author(s).

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Auteurs

Vasiliki Lagou (V)

Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Human Genetics, Wellcome Sanger Institute, Hinxton, UK.
VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.

Longda Jiang (L)

Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.

Anna Ulrich (A)

Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.

Liudmila Zudina (L)

Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.

Karla Sofia Gutiérrez González (KSG)

Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Department of Molecular Diagnostics, Clinical Laboratory, Clinica Biblica Hospital, San José, Costa Rica.
ORCID: 0009-0006-1948-9047

Zhanna Balkhiyarova (Z)

Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.
People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK.

Alessia Faggian (A)

Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.
Laboratory for Artificial Biology, Department of Cellular, Computational and Integrative Biology, University of Trento, Trento, Italy.
ORCID: 0000-0002-3799-9722

Jared G Maina (JG)

Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.
UMR 8199-EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France.

Shiqian Chen (S)

Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK.

Petar V Todorov (PV)

Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.

Sodbo Sharapov (S)

Laboratory of Glycogenomics, Institute of Cytology and Genetics SD RAS, Novosibirsk, Russia.
MSU Institute for Artificial Intelligence, Lomonosov Moscow State University, Moscow, Russia.

Alessia David (A)

Centre for Bioinformatics and System Biology, Department of Life Sciences, Imperial College London, London, UK.
ORCID: 0000-0001-8687-024X

Letizia Marullo (L)

Department of Evolutionary Biology, Genetic Section, University of Ferrara, Ferrara, Italy.

Reedik Mägi (R)

Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
ORCID: 0000-0002-2964-6011

Roxana-Maria Rujan (RM)

Centre for Sports, Exercise and Life Sciences, Coventry University, Conventry, UK.

Emma Ahlqvist (E)

Lund University Diabetes Centre, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
ORCID: 0000-0002-6513-2384

Gudmar Thorleifsson (G)

deCODE genetics/Amgen, Inc., Reykjavik, Iceland.
ORCID: 0000-0003-4623-9087

Ηe Gao (Η)

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.

Εvangelos Εvangelou (Ε)

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
ORCID: 0000-0002-5488-2999

Beben Benyamin (B)

Australian Centre for Precision Health, University of South Australia, Adelaide, South Australia, Australia.
Allied Health and Human Performance, University of South Australia, Adelaide, South Australia, Australia.
South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.

Robert A Scott (RA)

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
ORCID: 0000-0003-3634-3016

Aaron Isaacs (A)

Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
CARIM School for Cardiovascular Diseases and Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, the Netherlands.
Department of Physiology, Maastricht University, Maastricht, the Netherlands.
ORCID: 0000-0001-5037-4834

Jing Hua Zhao (JH)

Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Sara M Willems (SM)

Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.

Toby Johnson (T)

Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Christian Gieger (C)

Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.
Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
German Center for Diabetes Research (DZD), Neuherberg, Germany.
ORCID: 0000-0001-6986-9554

Harald Grallert (H)

Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.
German Center for Diabetes Research (DZD), Neuherberg, Germany.

Christa Meisinger (C)

Epidemiology, Faculty of Medicine, University of Augsburg, Augsburg, Germany.

Martina Müller-Nurasyid (M)

Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
IBE, Faculty of Medicine, LMU Munich, Munich, Germany.
Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.
Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany.

Rona J Strawbridge (RJ)

Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.
School of Health and Wellbeing, University of Glasgow, Glasgow, UK.
ORCID: 0000-0001-8506-3585

Anuj Goel (A)

Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
ORCID: 0000-0003-2307-4021

Denis Rybin (D)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

Eva Albrecht (E)

Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

Anne U Jackson (AU)

Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0002-9672-2547

Heather M Stringham (HM)

Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0002-2991-6392

Ivan R Corrêa (IR)

New England Biolabs, Ipswich, MA, USA.
ORCID: 0000-0002-3169-6878

Eric Farber-Eger (E)

Vanderbilt Institute for Clinical and Translational Research and Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, TN, USA.
ORCID: 0000-0003-0281-3796

Valgerdur Steinthorsdottir (V)

deCODE genetics/Amgen, Inc., Reykjavik, Iceland.
ORCID: 0000-0003-1846-6274

André G Uitterlinden (AG)

Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
ORCID: 0000-0002-7276-3387

Patricia B Munroe (PB)

Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
ORCID: 0000-0002-4176-2947

Morris J Brown (MJ)

Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
ORCID: 0000-0001-8409-1082

Julian Schmidberger (J)

Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany.

Oddgeir Holmen (O)

Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway.

Barbara Thorand (B)

Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
German Center for Diabetes Research (DZD), Neuherberg, Germany.
ORCID: 0000-0002-8416-6440

Kristian Hveem (K)

K G Jebsen Centre for Genetic Epdiemiology, Department of Public Health and General Practice, Norwegian University of Science and Technology, Trondheim, Norway.

Tom Wilsgaard (T)

Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.
Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.
ORCID: 0000-0002-2709-9472

Karen L Mohlke (KL)

Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
ORCID: 0000-0001-6721-153X

Zhe Wang (Z)

The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
ORCID: 0000-0002-8046-4969

Aleksey Shmeliov (A)

Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.

Marcel den Hoed (M)

The Beijer Laboratory and Department of Immunology, Genetics and Pathology, Uppsala University and SciLifeLab, Uppsala, Sweden.
ORCID: 0000-0001-8081-428X

Ruth J F Loos (RJF)

Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.

Wolfgang Kratzer (W)

Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany.

Mark Haenle (M)

Department of Internal Medicine I, Ulm University Medical Centre, Ulm, Germany.

Wolfgang Koenig (W)

Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.
German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.
Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany.
ORCID: 0000-0002-2064-9603

Bernhard O Boehm (BO)

Lee Kong Chian School of Medicine, Nanyang Technological University Singapore, Singapore and Department of Endocrinology, Tan Tock Seng Hospital, Singapore City, Singapore.

Tricia M Tan (TM)

Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK.

Alejandra Tomas (A)

Section of Cell Biology and Functional Genomics, Imperial College London, London, UK.

Victoria Salem (V)

Department of Bioengineering, Imperial College London, South Kensington Campus, London, UK.

Inês Barroso (I)

Exeter Centre of Excellence for Diabetes Research (EXCEED), University of Exeter Medical School, Exeter, UK.
ORCID: 0000-0001-5800-4520

Jaakko Tuomilehto (J)

Public Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Department of Public Health, University of Helsinki, Helsinki, Finland.
Diabetes Research Unit, King Abdulaziz University, Jeddah, Saudi Arabia.
ORCID: 0000-0002-3424-0745

Michael Boehnke (M)

Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
ORCID: 0000-0002-6442-7754

Jose C Florez (JC)

Center for Genomic Medicine and Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.
Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Department of Medicine, Harvard Medical School, Boston, MA, USA.

Anders Hamsten (A)

Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.

Hugh Watkins (H)

Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

Inger Njølstad (I)

Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.
Department of Clinical Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway.

H-Erich Wichmann (HE)

Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.

Mark J Caulfield (MJ)

Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
ORCID: 0000-0001-9295-3594

Kay-Tee Khaw (KT)

Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Cornelia M van Duijn (CM)

Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Centre for Medical Systems Biology, Leiden, the Netherlands.
Nuffield Department of Population Health, University of Oxford, Oxford, UK.
ORCID: 0000-0002-2374-9204

Albert Hofman (A)

Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Netherlands Consortium for Healthy Ageing, the Hague, the Netherlands.

Nicholas J Wareham (NJ)

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
ORCID: 0000-0003-1422-2993

Claudia Langenberg (C)

MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Computational Medicine, Berlin Institute of Health at Charité-Universitätsmedizin Berlin, Berlin, Germany.
Precision Healthcare University Research Institute, Queen Mary University of London, London, UK.
ORCID: 0000-0002-5017-7344

John B Whitfield (JB)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Nicholas G Martin (NG)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.

Grant Montgomery (G)

QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia.
ORCID: 0000-0002-4140-8139

Chiara Scapoli (C)

Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.

Ioanna Tzoulaki (I)

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
ORCID: 0000-0002-4275-9328

Paul Elliott (P)

Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
MRC Centre for Environment and Health, Imperial College London, London, UK.
National Institute for Health Research Imperial College London Biomedical Research Centre, Imperial College London, London, UK.
ORCID: 0000-0002-7511-5684

Unnur Thorsteinsdottir (U)

deCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Faculty of Medicine, University of Iceland, Reykjavík, Iceland.

Kari Stefansson (K)

deCODE genetics/Amgen, Inc., Reykjavik, Iceland.
Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
ORCID: 0000-0003-1676-864X

Evan L Brittain (EL)

Vanderbilt University Medical Center and the Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, TN, USA.
ORCID: 0000-0001-5843-3392

Mark I McCarthy (MI)

Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Genentech, South San Francisco, CA, USA.
ORCID: 0000-0002-4393-0510

Philippe Froguel (P)

Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
UMR 8199-EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France.
ORCID: 0000-0003-2972-0784

Patrick M Sexton (PM)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

Denise Wootten (D)

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
ARC Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

Leif Groop (L)

Lund University Diabetes Centre, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Finnish Institute for Molecular Medicine (FIMM), Helsinki University, Helsinki, Finland.
ORCID: 0000-0002-0187-3263

Josée Dupuis (J)

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.
ORCID: 0000-0003-2871-3603

James B Meigs (JB)

Programs in Metabolism and Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Department of Medicine, Harvard Medical School, Boston, MA, USA.
Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA.
ORCID: 0000-0002-2439-2657

Giuseppe Deganutti (G)

Centre for Sports, Exercise and Life Sciences, Coventry University, Conventry, UK.
ORCID: 0000-0001-8780-2986

Ayse Demirkan (A)

Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK.
People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK.
Department of Genetics, University Medical Center Groningen, Groningen, the Netherlands.

Tune H Pers (TH)

Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0003-0207-4831

Christopher A Reynolds (CA)

Centre for Sports, Exercise and Life Sciences, Coventry University, Conventry, UK.
School of Life Sciences, University of Essex, Colchester, UK.

Yurii S Aulchenko (YS)

Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Laboratory of Glycogenomics, Institute of Cytology and Genetics SD RAS, Novosibirsk, Russia.
MSU Institute for Artificial Intelligence, Lomonosov Moscow State University, Moscow, Russia.
ORCID: 0000-0002-7899-1575

Marika A Kaakinen (MA)

Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. m.kaakinen@imperial.ac.uk.
Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK. m.kaakinen@imperial.ac.uk.
People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK. m.kaakinen@imperial.ac.uk.

Ben Jones (B)

Section of Endocrinology and Investigative Medicine, Imperial College London, London, UK. ben.jones@imperial.ac.uk.
ORCID: 0000-0003-0461-2584

Inga Prokopenko (I)

Department of Clinical and Experimental Medicine, School of Biosciences and Medicine, University of Surrey, Guildford, UK. i.prokopenko@surrey.ac.uk.
People-Centred Artificial Intelligence Institute, University of Surrey, Guildford, UK. i.prokopenko@surrey.ac.uk.
UMR 8199-EGID, Institut Pasteur de Lille, CNRS, University of Lille, Lille, France. i.prokopenko@surrey.ac.uk.
ORCID: 0000-0003-1624-7457

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › GWAS of random glucose in 476,326 individuals...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › GWAS of random glucose in 476,326 individuals...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › GWAS of random glucose in 476,326 individuals...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glycémie › GWAS of random glucose in 476,326 individuals...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › GWAS of random glucose in 476,326 individuals...
questionsmedicales.fr › Système digestif › Tube digestif › Tube digestif inférieur › Gros intestin › Côlon › GWAS of random glucose in 476,326 individuals...